RevvityPhenoVue anti-Phospho H2AX (S139) - Mouse IgG1 Antibody, 100x

DNA damage ranges from single-strand breaks (SSBs) to double-strand breaks (DSBs) and complex base modifications. DSBs are the most harmful, leading to genomic instability or cell death if unrepaired. Cells activate the DNA damage response (DDR) to detect and repair damage, crucial for studying genome stability, assessing cytotoxic agents, and developing anticancer drugs.

γ-H2AX (phosphorylated H2AX on Ser139) serves as a key biomarker of DSBs, as its rapid phosphorylation at damage sites is essential for DDR activation. The PhenoVue anti-Phospho H2AX (S139) - mouse IgG1 antibody, part of the PhenoVue DNA Damage Response Staining Kit (PDDR11), supports imaging and high-content analysis applications.