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Cayman PF-06446846 (hydrochloride), 10 mg
List Price $262.00 Your Price $262.00
Cayman PF-06446846 (hydrochloride), 10 mg-CAYM (Additional S&H Or Hazmat Fees May Apply)
NETA PART: CAYM-20914-10
MFG.PART: 20914-10
UNSPSC: 12352203
Manufacturer: Cayman
Product Description
PF-06446846 is an inhibitor of proprotein convertase subtilisin kexin type 9 (PCSK9) translation.1 It inhibits translation of mRNA encoding PCSK9 by isolated human ribosomes when used at a concentration of 100 µM. PF-06446846 also inhibits PCSK9 secretion by Huh7 cells (IC50 = 0.3 µM). In vivo, PF-06446846 (50 mg/kg) decreases plasma levels of Pcsk9, total cholesterol, and LDL cholesterol in rats.
WARNING This product is not for human or veterinary use.
Technical Information
| Formal Name | N-(3-chloro-2- |
| CAS Number | 1632250-50-0 |
| Molecular Formula | C22H20ClN7O • XHCl |
| Formula Weight | 433.9 |
| Purity | ≥98% |
| Formulation(Request formulation change) | A solid |
| Solubility(Learn about Variance in Solubility) | Acetonitrile:Water (1:1): Slightly soluble: 0.1-1 mg/mLDMSO: Slightly soluble: 0.1-1 mg/mL |
| SMILES | ClC1=CC=CN=C1N([C@H]2CNCCC2)C(C3=CC=C(N4N=NC5=C4N=CC=C5)C=C3)=O.Cl |
| InChi Code | InChI=1S/C22H20ClN7O.ClH/c23-18-5-2-12-25-20(18)29(17-4-1-11-24-14-17)22(31)15-7-9-16(10-8-15)30-21-19(27-28-30)6-3-13-26-21;/h2-3,5-10,12-13,17,24H,1,4,11,14H2;1H/t17-;/m1./s1 |
| InChi Key | AQSJYIVIWBIHOU-UNTBIKODSA-N |
Shipping & Storage Information
| Storage | -20°C |
| Shipping | Room temperature in continental US; may vary elsewhere |
| Stability | ≥ 4 years |
| SKU | CAYM-20914-10 |
|---|---|
| Supplier Part Number | 20914-10 |
| UM | EA |
| UNSPSC | 12352203 |
| Manufacturer | Cayman |
| Temperature | -20 |
| Refrigerated-Frozen | Y |
| ProductLine | CAYM |
| Qty | 1 |
| MinOrderQty | 1 |
| Weight | 7.000000 |
| Lead Time | 5 |
| Hazardous | N |
| CAS Number | 1632250-50-0 |
| Energy Star | No |
| Green | No |
| Controlled | N |