We use cookies to make your experience better. To comply with the new e-Privacy directive, we need to ask for your consent to set the cookies. Learn about our cookie policy.
Cayman BI-9321 (hydrochloride), 1 mg
List Price $53.00 Your Price $53.00
Cayman BI-9321 (hydrochloride), 1 mg-CAYM (Additional S&H Or Hazmat Fees May Apply)
NETA PART: CAYM-27815-1
MFG.PART: 27815-1
UNSPSC: 12352200
Manufacturer: Cayman
Product Description
BI-9321 is an antagonist of the histone-lysine N-methyltransferase NSD3 (IC50 = 0.203 µM in a time-resolved FRET (TR-FRET) assay).1 It selectively binds to the NSD3 PWWP1 domain over 14 other PWWP domains, including NSD2-PWWP1 and NSD3-PWWP2, at 100 µM. BI-9321 is also selective for NSD3 over 20 methyllysine-binding proteins in differential static light scattering (DSLS) assays at 500 µM, 35 DNA or RNA methyltransferases in enzyme activity assays at 10 µM, and 31 kinases in enzyme activity assays at 10 µM. It decreases expression of mRNA encoding Myc in MOLM-13 acute myeloid leukemia (AML) cells when used at a concentration of 10 µM for six hours and reduces the viability of MOLM-13 cells after six days (IC50 = 26.8 µM).
WARNING This product is not for human or veterinary use.
Technical Information
| Formal Name | 4-[5-(7-fluoro- |
| CAS Number | 2387510-87-2 |
| Molecular Formula | C22H21FN4 • 3HCl |
| Formula Weight | 469.8 |
| Purity | ≥98% |
| Formulation | A solid |
| Solubility(Learn about Variance in Solubility) | Acetonitrile: Slightly soluble: 0.1-1 mg/mLDMSO: Slightly soluble: 0.1-1 mg/mL |
| SMILES | FC1=CC2=C(C(C3=C(C4=C(C)C=C(CN)C=C4C)N=CN3C)=CC=N2)C=C1.Cl.Cl.Cl |
| InChi Code | InChI=1S/C22H21FN4.3ClH/c1-13-8-15(11-24)9-14(2)20(13)21-22(27(3)12-26-21)18-6-7-25-19-10-16(23)4-5-17(18)19;;;/h4-10,12H,11,24H2,1-3H3;3*1H |
| InChi Key | DCDXMBVQCRHZMW-UHFFFAOYSA-N |
Shipping & Storage Information
| Storage | -20°C |
| Shipping | Room temperature in continental US; may vary elsewhere |
| Stability | ≥ 4 years |
| SKU | CAYM-27815-1 |
|---|---|
| Supplier Part Number | 27815-1 |
| UM | EA |
| UNSPSC | 12352200 |
| Manufacturer | Cayman |
| Temperature | -20 |
| Refrigerated-Frozen | Y |
| CountryOfOrigin | United States |
| ProductLine | CAYM |
| Qty | 1 |
| MinOrderQty | 1 |
| Weight | 7.000000 |
| Lead Time | 5 |
| Hazardous | N |
| CAS Number | 2387510-87-2 |
| Energy Star | No |
| Green | No |
| Controlled | N |