Cayman ACSL4 (42-711) (human, recombinant), 20 µg

Product Description

Long-chain acyl-CoA synthetase 4 (ACSL4) is a CoA ligase and member of the ACSL family.^1,2 It is composed of an N-terminal membrane-binding domain, a transmembrane domain, an adenosine adaptor region, and a C-terminal catalytic domain.² ACSL4 is primarily found in the mitochondria, peroxisomes, endoplasmic reticulum (ER), and plasma membrane.^1,3 It is generally involved in fatty acid degradation via β-oxidation and lipid synthesis.² Specifically, ACSL4 ligates 20-chain PUFAs, such as eicosapentaenoic acid (Item Nos. 90110 | 90110.1 | 21908) or arachidonic acid (Item Nos. 90010 | 90010.1 | 10006607), to CoA to form fatty acyl-CoA esters, which are then used for lipid synthesis, plasma membrane repair, and as a carbon source in the citric acid cycle, among other processes.^2,4 However, this process can be dysregulated by increased intracellular levels of ferrous iron (Fe²⁺) and reactive oxygen species (ROS) that further oxidize these PUFA fatty acyl-CoA esters into lipid peroxides that contribute to the development of ferroptosis.^3,5,6 Increased expression of ACSL4 is associated with higher cancer staging in patients with prostate cancer.⁷ Caymans ACSL4 (42-711) (human, recombinant) protein can be used for enzyme activity, ELISA, and Western blot (WB) applications.

WARNING This product is not for human or veterinary use.

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