We use cookies to make your experience better. To comply with the new e-Privacy directive, we need to ask for your consent to set the cookies. Learn about our cookie policy.
Cayman (R)-C12-200, 10 mg
List Price $207.00 Your Price $207.00
Cayman (R)-C12-200, 10 mg-CAYM (Additional S&H Or Hazmat Fees May Apply)
NETA PART: CAYM-43647-10
MFG.PART: 43647-10
UNSPSC: 41122409
Manufacturer: Cayman
Product Description
(R)-C12-200 is an ionizable cationic lipid (pKa = 7.25) and isomer of C12-200 (Item No. 36699) that has been used in the formation of lipid nanoparticles (LNPs) for the delivery of mRNA in vivo.1 Intravenous administration of LNPs containing (R)-C12-200 and encapsulating mRNA encoding Cre recombinase increases the percentage of tdTomato+ hepatocytes, endothelial cells, and Kupffer cells in the liver of Ai14 mice to a lesser extent than LNPs containing (S)-C12-200 (Item No. 38885) and encapsulating Cre recombinase. LNPs containing (R)-C12-200 and encapsulating mRNA encoding purine nucleoside phosphorylase (PNP), an E. coli enzyme that converts fludarabine phosphate (Item No. 14251) into the cytotoxic agent 2-fluoroadenine, induce intratumoral expression of PNP and reduce tumor volume in a FaDu head and neck squamous cell carcinoma (HNSCC) mouse xenograft model when co-administered with fludarabine phosphate.2
WARNING This product is not for human or veterinary use.
Technical Information
| Formal Name | (2R,2′R)-1,1′-[[2-[4-[2-[[2-[bis[(2R)-2-hydroxydodecyl]amino]ethyl][(2R)-2-hydroxydodecyl]amino]ethyl]-1-piperazinyl]ethyl]imino]bis-2-dodecanol |
| CAS Number | 1226777-45-2 |
| Synonyms |
|
| Molecular Formula | C70H145N5O5 |
| Formula Weight | 1137.0 |
| Purity | ≥98% |
| Formulation(Request formulation change) | A 50 mg/mL solution in ethanol |
| Solubility(Learn about Variance in Solubility) | Ethanol: Soluble: ≥10 mg/mL |
| SMILES | O[C@H](CCCCCCCCCC)CN(CCN(C[C@@H](CCCCCCCCCC)O)C[C@@H](CCCCCCCCCC)O)CCN1CCN(CCN(C[C@@H](CCCCCCCCCC)O)C[C@@H](CCCCCCCCCC)O)CC1 |
| InChi Code | InChI=1S/C70H145N5O5/c1-6-11-16-21-26-31-36-41-46-66(76)61-73(58-60-75(64-69(79)49-44-39-34-29-24-19-14-9-4)65-70(80)50-45-40-35-30-25-20-15-10-5)57-55-71-51-53-72(54-52-71)56-59-74(62-67(77)47-42-37-32-27-22-17-12-7-2)63-68(78)48-43-38-33-28-23-18-13-8-3/h66-70,76-80H,6-65H2,1-5H3/t66-,67-,68-,69-,70-/m1/s1 |
| InChi Key | RVHYPUORVDKRTM-ZSTXVYJSSA-N |
Shipping & Storage Information
| Storage | -20°C |
| Shipping | Wet ice in continental US; may vary elsewhere |
| Stability | ≥ 3 years |
| SKU | CAYM-43647-10 |
|---|---|
| Supplier Part Number | 43647-10 |
| UM | EA |
| UNSPSC | 41122409 |
| Manufacturer | Cayman |
| MSDS URL | Click here |
| Temperature | -20 |
| Refrigerated-Frozen | Y |
| CountryOfOrigin | United States |
| ProductLine | CAYM |
| Qty | 1 |
| MinOrderQty | 1 |
| Weight | 7.000000 |
| Lead Time | 5 |
| Hazardous | Y |
| CAS Number | 1226777-45-2 |
| Energy Star | No |
| Green | No |
| Controlled | N |