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Cayman BAY-8400, 1 mg
List Price
$83.00
Your Price
$83.00
Cayman BAY-8400, 1 mg-CAYM (Additional S&H Or Hazmat Fees May Apply)
NETA PART:
CAYM-43707-1
MFG.PART:
43707-1
UNSPSC:
12352200
Manufacturer:
Cayman
Product Description
BAY-8400 is an inhibitor of DNA-dependent protein kinase (DNA-PK; IC50 = 0.081 µM).1 It is selective for DNA-PK over ataxia-telangiectasia mutated kinase (ATM) and mTOR (IC50s = 19.3 and 1.91 µM, respectively) and a panel of 365 additional kinases at 1 µM but does inhibit ataxia-telangiectasia and Rad3-related protein/kinase (ATR) and PI3Kβ (IC50s = 0.394 and 0.117 µM, respectively). BAY-8400 inhibits the formation of γH2AX in ATM-negative HT-144 melanoma cells (IC50 = 0.069 nM) and reduces the proliferation of HT-29 colon cancer cells when used alone or in combination with bleomycin. In vivo, BAY-8400 (150 mg/kg, p.o.) reduces tumor area in an LNCaP prostate cancer mouse xenograft model when administered in combination with BAY 2315497.
WARNING This product is not for human or veterinary use.
Technical Information
| Formal Name | 8-[5-(difluoro |
| CAS Number | 2763602-59-9 |
| Molecular Formula | C21H17F2N5O |
| Formula Weight | 393.4 |
| Purity | ≥98% |
| Formulation(Request formulation change) | A solid |
| Solubility(Learn about Variance in Solubility) | Acetonitrile: Slightly soluble: 0.1-1 mg/mLDMSO: Slightly soluble: 0.1-1 mg/mL |
| SMILES | FC(F)C1=CN=CC(C2=CC3=C(C=C2)N=CC4=NN=C(C5=CCCOCC5)N34)=C1 |
| InChi Code | InChI=1S/C21H17F2N5O/c22-20(23)16-8-15(10-24-11-16)14-3-4-17-18(9-14)28-19(12-25-17)26-27-21(28)13-2-1-6-29-7-5-13/h2-4,8-12,20H,1,5-7H2 |
| InChi Key | ATKHYZXUMVNCIO-UHFFFAOYSA-N |
Shipping & Storage Information
| Storage | -20°C |
| Shipping | Room temperature in continental US; may vary elsewhere |
| Stability | ≥ 4 years |
| SKU | CAYM-43707-1 |
|---|---|
| Supplier Part Number | 43707-1 |
| UM | EA |
| UNSPSC | 12352200 |
| Manufacturer | Cayman |
| Temperature | -20 |
| Refrigerated-Frozen | Y |
| CountryOfOrigin | China |
| ProductLine | CAYM |
| Qty | 1 |
| MinOrderQty | 1 |
| Weight | 7.000000 |
| Lead Time | 5 |
| Hazardous | N |
| CAS Number | 2763602-59-9 |
| Energy Star | No |
| Green | No |
| Controlled | N |