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Cayman Tissue Factor/CD142 (human) Monoclonal Antibody, 100 µl
List Price
$269.00
Your Price
$269.00
Cayman Tissue Factor/CD142 (human) Monoclonal Antibody, 100 µl-CAYM (Additional S&H Or Hazmat Fees May Apply)
NETA PART:
CAYM-43763-100
MFG.PART:
43763-100
UNSPSC:
12352203
Manufacturer:
Cayman
Product Description
Tissue factor (TF), also known as CD142, is a type I transmembrane single-chain glycoprotein and the primary activator of the exogenous coagulation pathway.1,2 It is composed of an extracellular domain, which contains two fibronectin type III domains and interacts with factor VIIa (FVIIa), a transmembrane domain, and a cytoplasmic domain involved in signal transduction.3 TF is expressed by perivascular cells, including pericytes, adventitial fibroblasts, and vascular smooth muscle cells (VSMCs) and localizes to the cell surface.2 Vascular injury exposes pre-formed TF-FVIIa complexes to its substrates, FX and FIX, initiating coagulation.2,3 TF levels and procoagulant activity are increased in atherosclerotic plaques isolated from patients with unstable coronary syndrome compared with those isolated from patients with stable coronary syndrome.2 Overexpression of F3, the gene encoding TF, is positively correlated with tumor angiogenesis in advanced liver, breast, pancreatic, and lung cancers.1 Caymans Tissue Factor (human) Monoclonal Antibody can be used for ELISA, flow cytometry (FC), immunocytochemistry (ICC), and immunofluorescence (IF) applications.
WARNING This product is not for human or veterinary use.
Technical Information
| Synonyms |
|
| Immunogen | Recombinant human TF |
| Clone Designation | Monoclonal, Clone #05 |
| Formulation(Request formulation change) | 100 µl of protein A purified monoclonal antibody |
| Storage Buffer | 0.2 μm filtered solution in PBS |
| Host | Mouse |
| Isotype | IgG2a |
| Applications | ELISA, FC, ICC, IF |
| Cross Reactivity | (+) Human tissue factor(-) HEK293 cell lysate |
| Species Reactivity | (+) Human |
Shipping & Storage Information
| Storage | -80°C |
| Shipping | Dry ice in continental US; may vary elsewhere |
| Stability | ≥ 1 year |
| SKU | CAYM-43763-100 |
|---|---|
| Supplier Part Number | 43763-100 |
| UM | EA |
| UNSPSC | 12352203 |
| Manufacturer | Cayman |
| Temperature | -80 |
| Refrigerated-Frozen | Y |
| CountryOfOrigin | United States |
| ProductLine | CAYM |
| Qty | 1 |
| MinOrderQty | 1 |
| Weight | 7.000000 |
| Lead Time | 5 |
| Hazardous | N |
| Energy Star | No |
| Green | No |
| Controlled | N |