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Cayman Mitapivat, 10 mg
List Price $158.00 Your Price $158.00
Cayman Mitapivat, 10 mg-CAYM (Additional S&H Or Hazmat Fees May Apply)
NETA PART: CAYM-43908-10
MFG.PART: 43908-10
UNSPSC: 51180000
Manufacturer: Cayman
Product Description
Mitapivat is an allosteric activator of erythrocyte pyruvate kinase (PKR).1 It increases PKR activity and ATP levels in red blood cells isolated from patients with pyruvate kinase deficiency when used at a concentration of 10 µM. Mitapivat increases hematocrit and hemoglobin levels, decreases osmotic fragility, and reduces splenic erythrophagocytosis in a model of hereditary spherocytosis using protein 4.2 knockout (4.2-/-) mice.2 Formulations containing mitapivat have been used in the treatment of hemolytic anemia in patients with pyruvate kinase deficiency.
WARNING This product is not for human or veterinary use.
Technical Information
| Formal Name | N-[4-[[4-(cyclo |
| CAS Number | 1260075-17-9 |
| Synonyms |
|
| Molecular Formula | C24H26N4O3S |
| Formula Weight | 450.6 |
| Purity | ≥98% |
| Formulation(Request formulation change) | A solid |
| Solubility(Learn about Variance in Solubility) | DMSO: Slightly soluble: 0.1-1 mg/mL |
| SMILES | O=C(N1CCN(CC2CC2)CC1)C3=CC=C(NS(C4=CC=CC5=CC=CN=C45)(=O)=O)C=C3 |
| InChi Code | InChI=1S/C24H26N4O3S/c29-24(28-15-13-27(14-16-28)17-18-6-7-18)20-8-10-21(11-9-20)26-32(30,31)22-5-1-3-19-4-2-12-25-23(19)22/h1-5,8-12,18,26H,6-7,13-17H2 |
| InChi Key | XAYGBKHKBBXDAK-UHFFFAOYSA-N |
Shipping & Storage Information
| Storage | -20°C |
| Shipping | Room temperature in continental US; may vary elsewhere |
| Stability | ≥ 4 years |
| SKU | CAYM-43908-10 |
|---|---|
| Supplier Part Number | 43908-10 |
| UM | EA |
| UNSPSC | 51180000 |
| Manufacturer | Cayman |
| Temperature | -20 |
| Refrigerated-Frozen | Y |
| CountryOfOrigin | China |
| ProductLine | CAYM |
| Qty | 1 |
| MinOrderQty | 1 |
| Weight | 7.000000 |
| Lead Time | 5 |
| Hazardous | Y |
| CAS Number | 1260075-17-9 |
| Energy Star | No |
| Green | No |
| Controlled | N |