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Cayman EZM0414, 1 mg
List Price $219.00 Your Price $219.00
Cayman EZM0414, 1 mg-CAYM (Additional S&H Or Hazmat Fees May Apply)
NETA PART: CAYM-43914-1
MFG.PART: 43914-1
UNSPSC: 12352200
Manufacturer: Cayman
Product Description
EZM0414 is an inhibitor of SET domain-containing protein 2 (SETD2; IC50 = 18 nM).1 It inhibits the proliferation of A549 non-small cell lung cancer (NSCLC) cells (EC50 = 57 nM). EZM0414 (15 and 30 mg/kg) decreases tumor volume in a KMS-11 multiple myeloma mouse xenograft model. It decreases cardiomyocyte levels of trimethylated lysine 36 on histone H3 (H3K36Me3) in a mouse model of heart failure with preserved ejection fraction (HFpEF) induced by a high-fat diet and L-NAME (Item No. 80210).2 EZM0414 also reduces lung congestion and cardiac hypertrophy in the same model.
WARNING This product is not for human or veterinary use.
Technical Information
| Formal Name | N-[(1R,3S)-3- |
| CAS Number | 2411748-50-8 |
| Molecular Formula | C22H29FN4O2 |
| Formula Weight | 400.5 |
| Purity | ≥98% |
| Formulation(Request formulation change) | A solid |
| Solubility(Learn about Variance in Solubility) | DMSO: Slightly soluble: 0.1-1 mg/mLEthanol: Slightly soluble: 0.1-1 mg/mL |
| SMILES | FC1=C2C(NC(C(N[C@@H]3CCC[C@@H](C3)N4CCN(CC4)C(C)=O)=O)=C2)=C(C=C1)C |
| InChi Code | InChI=1S/C22H29FN4O2/c1-14-6-7-19(23)18-13-20(25-21(14)18)22(29)24-16-4-3-5-17(12-16)27-10-8-26(9-11-27)15(2)28/h6-7,13,16-17,25H,3-5,8-12H2,1-2H3,(H,24,29)/t16-,17+/m1/s1 |
| InChi Key | PGNLXEBQMQHFNK-SJORKVTESA-N |
Shipping & Storage Information
| Storage | -20°C |
| Shipping | Room temperature in continental US; may vary elsewhere |
| Stability | ≥ 4 years |
| SKU | CAYM-43914-1 |
|---|---|
| Supplier Part Number | 43914-1 |
| UM | EA |
| UNSPSC | 12352200 |
| Manufacturer | Cayman |
| Temperature | -20 |
| Refrigerated-Frozen | Y |
| CountryOfOrigin | United States |
| ProductLine | CAYM |
| Qty | 1 |
| MinOrderQty | 1 |
| Weight | 7.000000 |
| Lead Time | 5 |
| Hazardous | N |
| CAS Number | 2411748-50-8 |
| Energy Star | No |
| Green | No |
| Controlled | N |