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Cayman KRCA 0008, 10 mg
List Price
$63.00
Your Price
$63.00
Cayman KRCA 0008, 10 mg-CAYM (Additional S&H Or Hazmat Fees May Apply)
NETA PART:
CAYM-43933-10
MFG.PART:
43933-10
UNSPSC:
12352107
Manufacturer:
Cayman
Product Description
KRCA 0008 is an inhibitor of anaplastic lymphoma kinase (ALK) and tyrosine non-receptor kinase 2 (TNK2), also known as activated Cdc42 kinase 1 (ACK1; IC50s = 12 and 4 nM, respectively).1 It is selective for these kinases over the insulin receptor (InsR; IC50 = 210 nM). KRCA 0008 also inhibits the ALK mutants ALKL1196M, ALKC1156Y, ALKF1174L, and ALKR1275Q (IC50s = 75, 4, 171, and 17 nM, respectively).2 It selectively reduces the proliferation of NCI H3122 lung cancer cells, which are driven by the EML4-ALK fusion protein, over NCI H1993 lung cancer cells, which are driven by c-Met (IC50s = 80 and 3,600 nM, respectively). KRCA 0008 (25 and 50 mg/kg) reduces tumor volume in an NCI H3122 mouse xenograft model.
WARNING This product is not for human or veterinary use.
Technical Information
| Formal Name | 1-phenylene)-4,1-piperazinediyl]]bis-1,1′-[(5-chloro-2,4-pyrimidinediyl)bis[imino(3-methoxy-4 ethanone |
| CAS Number | 1472795-20-2 |
| Molecular Formula | C30H37ClN8O4 |
| Formula Weight | 609.1 |
| Purity | ≥95% |
| Formulation(Request formulation change) | A solid |
| Solubility(Learn about Variance in Solubility) | DMSO: Sparingly soluble: 1-10 mg/mL |
| SMILES | O=C(C)N1CCN(CC1)C2=CC=C(C(OC)=C2)NC3=NC=C(C(NC(C(OC)=C4)=CC=C4N5CCN(CC5)C(C)=O)=N3)Cl |
| InChi Code | InChI=1S/C30H37ClN8O4/c1-20(40)36-9-13-38(14-10-36)22-5-7-25(27(17-22)42-3)33-29-24(31)19-32-30(35-29)34-26-8-6-23(18-28(26)43-4)39-15-11-37(12-16-39)21(2)41/h5-8,17-19H,9-16H2,1-4H3,(H2,32,33,34,35) |
| InChi Key | TXDIRJCYNAWBOS-UHFFFAOYSA-N |
Shipping & Storage Information
| Storage | -20°C |
| Shipping | Room temperature in continental US; may vary elsewhere |
| Stability | ≥ 4 years |
| SKU | CAYM-43933-10 |
|---|---|
| Supplier Part Number | 43933-10 |
| UM | EA |
| UNSPSC | 12352107 |
| Manufacturer | Cayman |
| MSDS URL | Click here |
| Temperature | -20 |
| Refrigerated-Frozen | Y |
| CountryOfOrigin | China |
| ProductLine | CAYM |
| Qty | 1 |
| MinOrderQty | 1 |
| Weight | 7.000000 |
| Lead Time | 5 |
| Hazardous | N |
| CAS Number | 1472795-20-2 |
| Energy Star | No |
| Green | No |
| Controlled | N |