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Cayman BIO-5192, 1 mg
List Price $46.00 Your Price $46.00
Cayman BIO-5192, 1 mg-CAYM (Additional S&H Or Hazmat Fees May Apply)
NETA PART: CAYM-44105-1
MFG.PART: 44105-1
UNSPSC: 41116134
Manufacturer: Cayman
Product Description
BIO-5192 is an inhibitor of integrin α4β1, also known as very late antigen-4 (VLA-4; IC50 = 1.8 nM).1 It is selective for integrin α4β1 over the integrins α4β7, α9β1, and α2β1 (IC50s = >500, 138, and 1,053 nM, respectively). BIO-5192 (1 µg/mL) inhibits the adhesion of α4β1-expressing A20 cells to fibronectin-coated plates.2 It improves limb function in a rat model of experimental autoimmune encephalomyelitis (EAE) induced by myelin basic protein (MBP) peptide when administered at a dose of 30 mg/kg twice per day.1
WARNING This product is not for human or veterinary use.
Technical Information
| Formal Name | (2S)-2-[[[(2S)-1-[(3,5-dichlorophenyl)sulfonyl]-2-pyrrolidinyl]carbonyl]amino]-4-[[(2S)-4-methyl-2-[methyl[2-[4-[[[(2-methyl phenyl)amino]carbonyl]amino]phenyl]acetyl]amino]-1-oxopentyl] amino]-butanoic acid |
| CAS Number | 327613-57-0 |
| Synonyms |
|
| Molecular Formula | C38H46Cl2N6O8S |
| Formula Weight | 817.8 |
| Purity | ≥95% |
| Formulation(Request formulation change) | A solid |
| Solubility(Learn about Variance in Solubility) | Acetonitrile:Water (1:1): Slightly soluble: 0.1-1 mg/mLDMSO: Slightly soluble: 0.1-1 mg/mL |
| SMILES | ClC1=CC(S(N2CCC[C@H]2C(N[C@@H](CCNC([C@@H](N(C(CC3=CC=C(NC(NC4=C(C)C=CC=C4)=O)C=C3)=O)C)CC(C)C)=O)C(O)=O)=O)(=O)=O)=CC(Cl)=C1 |
| InChi Code | InChI=1S/C38H46Cl2N6O8S/c1-23(2)18-33(45(4)34(47)19-25-11-13-28(14-12-25)42-38(52)44-30-9-6-5-8-24(30)3)35(48)41-16-15-31(37(50)51)43-36(49)32-10-7-17-46(32)55(53,54)29-21-26(39)20-27(40)22-29/h5-6,8-9,11-14,20-23,31-33H,7,10,15-19H2,1-4H3,(H,41,48)(H,43,49)(H,50,51)(H2,42,44,52)/t31-,32-,33-/m0/s1 |
| InChi Key | MNQBPRHHZPXCKZ-ZDCRTTOTSA-N |
Shipping & Storage Information
| Storage | -20°C |
| Shipping | Room temperature in continental US; may vary elsewhere |
| Stability | ≥ 4 years |
| SKU | CAYM-44105-1 |
|---|---|
| Supplier Part Number | 44105-1 |
| UM | EA |
| UNSPSC | 41116134 |
| Manufacturer | Cayman |
| Temperature | -20 |
| Refrigerated-Frozen | Y |
| CountryOfOrigin | China |
| ProductLine | CAYM |
| Qty | 1 |
| MinOrderQty | 1 |
| Weight | 7.000000 |
| Lead Time | 5 |
| Hazardous | N |
| CAS Number | 327613-57-0 |
| Energy Star | No |
| Green | No |
| Controlled | N |