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Cayman Donitriptan (hydrochloride), 1 mg
List Price $40.00 Your Price $40.00
Cayman Donitriptan (hydrochloride), 1 mg-CAYM (Additional S&H Or Hazmat Fees May Apply)
NETA PART: CAYM-44116-1
MFG.PART: 44116-1
UNSPSC: 41116134
Manufacturer: Cayman
Product Description
Donitriptan is an agonist of the serotonin (5-HT) receptor subtypes 5-HT1B and 5-HT1D.1 It inhibits forskolin-induced cAMP formation in C6 cells expressing the human receptors (pD2 = 8.91 and 9.57, respectively). Donitriptan is selective for 5-HT1B and 5-HT1D (Kis = 0.36 and 0.15 nM, respectively, for the human receptors) over 5-HT1A, 5-HT1E, and 5-HT1F (Kis = 25, 1,148, and 3,388 nM, respectively) and 5-HT2A, 5-HT5A, 5-HT6, and 5-HT7 (Kis = 182, 813, 2,344, and 371 nM, respectively). It induces contractions in rabbit saphenous vein rings (pD2 = 7.1) and increases outward steady-state hyperpolarizing potassium currents (IK) in isolated guinea pig trigeminal ganglion cells when used at a concentration of 100 nM. In vivo, donitriptan (0.63 and 2.5 mg/kg) decreases total carotid blood flow and increases vascular resistance but does not affect mean arterial pressure or heart rate in anesthetized pigs.
WARNING This product is not for human or veterinary use.
Technical Information
| Formal Name | 4-[4-[2-[[3- |
| CAS Number | 170911-68-9 |
| Synonyms |
|
| Molecular Formula | C23H25N5O2 • HCl |
| Formula Weight | 439.9 |
| Purity | ≥98% |
| Formulation(Request formulation change) | A solid |
| Solubility(Learn about Variance in Solubility) | Acetonitrile: Slightly soluble: 0.1-1 mg/mLWater: Slightly soluble: 0.1-1 mg/mL |
| SMILES | N#CC1=CC=C(N2CCN(CC2)C(COC3=CC4=C(NC=C4CCN)C=C3)=O)C=C1.Cl |
| InChi Code | InChI=1S/C23H25N5O2.ClH/c24-8-7-18-15-26-22-6-5-20(13-21(18)22)30-16-23(29)28-11-9-27(10-12-28)19-3-1-17(14-25)2-4-19;/h1-6,13,15,26H,7-12,16,24H2;1H |
| InChi Key | ZXENQGQAPOYDOJ-UHFFFAOYSA-N |
Shipping & Storage Information
| Storage | -20°C |
| Shipping | Room temperature in continental US; may vary elsewhere |
| Stability | ≥ 4 years |
| SKU | CAYM-44116-1 |
|---|---|
| Supplier Part Number | 44116-1 |
| UM | EA |
| UNSPSC | 41116134 |
| Manufacturer | Cayman |
| Temperature | -20 |
| Refrigerated-Frozen | Y |
| CountryOfOrigin | China |
| ProductLine | CAYM |
| Qty | 1 |
| MinOrderQty | 1 |
| Weight | 7.000000 |
| Lead Time | 5 |
| Hazardous | Y |
| CAS Number | 170911-68-9 |
| Energy Star | No |
| Green | No |
| Controlled | N |