We use cookies to make your experience better. To comply with the new e-Privacy directive, we need to ask for your consent to set the cookies. Learn about our cookie policy.
Cayman Enzomenib, 1 mg
List Price
$138.00
Your Price
$138.00
Cayman Enzomenib, 1 mg-CAYM (Additional S&H Or Hazmat Fees May Apply)
NETA PART:
CAYM-44271-1
MFG.PART:
44271-1
UNSPSC:
12352201
Manufacturer:
Cayman
Product Description
Enzomenib is an inhibitor of the protein-protein interaction between menin and mixed-lineage leukemia 1 (MLL1).1 It binds to menin (Kd = 6 nM) and inhibits the menin-MLL1 interaction with an IC50 value of 1.4 nM. Enzomenib selectively inhibits the growth of MV4-11, MOLM-13, KOPN-8, and OCI-AML-3 leukemia cells (IC50s = 10, 15, 31, and 15 nM, respectively), which contain MLL rearrangement (MLL-r) or NPM1 mutations, over HL-60, MOLT-4, and Reh leukemia cells (IC50s = >10 µM for all), which do not have MLL-r or NPM1 mutations. In vivo, enzomenib (25 and 50 mg/kg) has antitumor activity in a mouse xenograft model using MV4-11 cells, which express an MLL-AF4 gene fusion.
WARNING This product is not for human or veterinary use.
Technical Information
| Formal Name | 5-fluoro-2-[[4- |
| CAS Number | 2412555-70-3 |
| Synonyms |
|
| Molecular Formula | C33H43FN6O3 |
| Formula Weight | 590.7 |
| Purity | ≥98% |
| Formulation(Request formulation change) | A solid |
| Solubility(Learn about Variance in Solubility) | Acetonitrile: Slightly Soluble: 0.1-1 mg/mLDMSO: Slightly Soluble: 0.1-1 mg/mL |
| SMILES | O=C([C@@H]1[C@@]2([H])C(C[C@@](CC2)([H])N1)=C)N3CCC4(CC3)CN(C4)C5=NC=NC=C5OC6=C(C(N(C(C)C)C(C)C)=O)C=C(F)C=C6 |
| InChi Code | InChI=1S/C33H43FN6O3/c1-20(2)40(21(3)4)31(41)26-15-23(34)6-9-27(26)43-28-16-35-19-36-30(28)39-17-33(18-39)10-12-38(13-11-33)32(42)29-25-8-7-24(37-29)14-22(25)5/h6,9,15-16,19-21,24-25,29,37H,5,7-8,10-14,17-18H2,1-4H3/t24-,25+,29-/m0/s1 |
| InChi Key | JQHJEDMMWUIYCE-FVVBACEJSA-N |
Shipping & Storage Information
| Storage | -20°C |
| Shipping | Room temperature in continental US; may vary elsewhere |
| Stability | ≥ 4 years |
| SKU | CAYM-44271-1 |
|---|---|
| Supplier Part Number | 44271-1 |
| UM | EA |
| UNSPSC | 12352201 |
| Manufacturer | Cayman |
| Temperature | -20 |
| Refrigerated-Frozen | Y |
| CountryOfOrigin | United States |
| ProductLine | CAYM |
| Qty | 1 |
| MinOrderQty | 1 |
| Weight | 7.000000 |
| Lead Time | 5 |
| Hazardous | N |
| CAS Number | 2412555-70-3 |
| Energy Star | No |
| Green | No |
| Controlled | N |