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Cayman RP 1664, 1 mg
List Price $138.00 Your Price $138.00
Cayman RP 1664, 1 mg-CAYM (Additional S&H Or Hazmat Fees May Apply)
NETA PART: CAYM-44283-1
MFG.PART: 44283-1
UNSPSC: 12352200
Manufacturer: Cayman
Product Description
RP 1664 is an inhibitor of polo-like kinase 4 (Plk4; IC50 = 3 nM).1 It induces centriole depletion in hTERT RPE-1 retinal pigment cells (EC50 = 0.13 µM). RP 1664 induces cytotoxicity in MCF-7 breast cancer cells (EC50 = 0.051 µM). It reduces tumor volume in a CAL-148 breast cancer mouse xenograft model when administered at doses of 11 or 21 mg/kg twice per day.
WARNING This product is not for human or veterinary use.
Technical Information
| Formal Name | 5-cyclopropyl- |
| CAS Number | 2980682-00-4 |
| Molecular Formula | C23H24F2N8O2S |
| Formula Weight | 514.6 |
| Purity | ≥95% |
| Formulation(Request formulation change) | A solid |
| Solubility(Learn about Variance in Solubility) | Acetonitrile: Slightly soluble: 0.1-1 mg/mLDMSO: Slightly soluble: 0.1-1 mg/mL |
| SMILES | CC1=CC(NC2=C(C3CC3)C(C4=CN(C)C=N4)=NC(N(C(C(F)=CC(S(C)(=O)=O)=C5)=C5F)C)=N2)=NN1 |
| InChi Code | InChI=1S/C23H24F2N8O2S/c1-12-7-18(31-30-12)27-22-19(13-5-6-13)20(17-10-32(2)11-26-17)28-23(29-22)33(3)21-15(24)8-14(9-16(21)25)36(4,34)35/h7-11,13H,5-6H2,1-4H3,(H2,27,28,29,30,31) |
| InChi Key | POKVQQVLRJLUAK-UHFFFAOYSA-N |
Shipping & Storage Information
| Storage | -20°C |
| Shipping | Room temperature in continental US; may vary elsewhere |
| Stability | ≥ 4 years |
| SKU | CAYM-44283-1 |
|---|---|
| Supplier Part Number | 44283-1 |
| UM | EA |
| UNSPSC | 12352200 |
| Manufacturer | Cayman |
| Temperature | -20 |
| Refrigerated-Frozen | Y |
| CountryOfOrigin | China |
| ProductLine | CAYM |
| Qty | 1 |
| MinOrderQty | 1 |
| Weight | 7.000000 |
| Lead Time | 5 |
| Hazardous | N |
| CAS Number | 2980682-00-4 |
| Energy Star | No |
| Green | No |
| Controlled | N |