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Cayman Edecesertib, 1 mg
List Price $127.00 Your Price $127.00
Cayman Edecesertib, 1 mg-CAYM (Additional S&H Or Hazmat Fees May Apply)
NETA PART: CAYM-44286-1
MFG.PART: 44286-1
UNSPSC: 12352211
Manufacturer: Cayman
Product Description
Edecesertib is an inhibitor of IL-1 receptor-associated kinase 4 (IRAK4; IC50 = 0.6 nM).1 It is selective for IRAK4 over a panel of 484 additional kinases at 1,000 nM. Edecesertib inhibits toll-like receptor 7 (TLR7) agonist-induced IFN-α production in isolated human whole blood (IC50 = 124 nM). Dietary administration of edecesertib (0.07% w/w in chow) reduces proteinuria and decreases plasma levels of TNF-α and IL-12 in an NZBWF1 mouse model of systemic lupus erythematosus (SLE).
WARNING This product is not for human or veterinary use.
Technical Information
| Formal Name | 4-[[(1R)-1- |
| CAS Number | 2408839-73-4 |
| Synonyms |
|
| Molecular Formula | C22H22FN7O2 |
| Formula Weight | 435.5 |
| Purity | ≥98% |
| Formulation(Request formulation change) | A solid |
| Solubility(Learn about Variance in Solubility) | DMSO: Soluble: ≥10 mg/mL |
| SMILES | N#C[C@@H](C)NC1=C(C(NC[C@H](C(C)(C)O)F)=O)C=NC(C2=CC=C3N2N=CC(C#N)=C3)=C1 |
| InChi Code | InChI=1S/C22H22FN7O2/c1-13(8-24)29-17-7-18(19-5-4-15-6-14(9-25)10-28-30(15)19)26-11-16(17)21(31)27-12-20(23)22(2,3)32/h4-7,10-11,13,20,32H,12H2,1-3H3,(H,26,29)(H,27,31)/t13-,20-/m1/s1 |
| InChi Key | HORBHQPSWJRDSV-ZUOKHONESA-N |
Shipping & Storage Information
| Storage | -20°C |
| Shipping | Room temperature in continental US; may vary elsewhere |
| Stability | ≥ 4 years |
| SKU | CAYM-44286-1 |
|---|---|
| Supplier Part Number | 44286-1 |
| UM | EA |
| UNSPSC | 12352211 |
| Manufacturer | Cayman |
| Temperature | -20 |
| Refrigerated-Frozen | Y |
| CountryOfOrigin | China |
| ProductLine | CAYM |
| Qty | 1 |
| MinOrderQty | 1 |
| Weight | 7.000000 |
| Lead Time | 5 |
| Hazardous | N |
| CAS Number | 2408839-73-4 |
| Energy Star | No |
| Green | No |
| Controlled | N |