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Cayman ABD957, 1 mg
List Price $655.00 Your Price $655.00
Cayman ABD957, 1 mg-CAYM (Additional S&H Or Hazmat Fees May Apply)
NETA PART: CAYM-44290-1
MFG.PART: 44290-1
UNSPSC: 12352200
Manufacturer: Cayman
Product Description
ABD957 is an inhibitor of α/β-hydrolase domain-containing protein 17 (ABHD17; IC50 = 0.21 µM for ABHD17B).1 It is selective for ABHD17A-C over a panel of 52 serine hydrolases, including the depalmitoylases ABHD10, palmitoyl-protein thioesterase 1 (PPT1), and lysophospholipase 1 (LYPLA1) and LYPLA2, at 10 µM but does inhibit ABHD6, ABHD11, ABHD13, and carboxylesterase 1 (CES1) and CES2 at the same concentration. ABD957 increases the palmitoylation of N-Ras in OCI-AML-3 acute myeloid leukemia (AML) cells expressing GFP-N-RasG12D (EC50 = 29 nM). It also increases the plasma membrane localization of N-Ras in the same cells when used at a concentration of 500 nM. ABD957 inhibits the growth of OCI-AML-3 cells in a concentration-dependent manner.
WARNING This product is not for human or veterinary use.
Technical Information
| Formal Name | 8-[2-[[(3S)-4- |
| CAS Number | 3007772-60-0 |
| Molecular Formula | C27H36F3N7O5S |
| Formula Weight | 627.7 |
| Purity | ≥98% |
| Formulation(Request formulation change) | A solid |
| Solubility(Learn about Variance in Solubility) | DMSO: Soluble |
| SMILES | C[C@H](N(CC1)C(N2N=C(C=C2)S(N(C)C)(=O)=O)=O)CN1CC3=C(N4C5CCC4CN(CC(O)=O)C5)C=C(C(F)(F)F)C=C3 |
| InChi Code | InChI=1S/C27H36F3N7O5S/c1-18-13-33(10-11-35(18)26(40)36-9-8-24(31-36)43(41,42)32(2)3)14-19-4-5-20(27(28,29)30)12-23(19)37-21-6-7-22(37)16-34(15-21)17-25(38)39/h4-5,8-9,12,18,21-22H,6-7,10-11,13-17H2,1-3H3,(H,38,39)/t18-,21?,22?/m0/s1 |
| InChi Key | ISNXAOFEMNFJCO-XTWGIRIWSA-N |
Shipping & Storage Information
| Storage | -20°C |
| Shipping | Room temperature in continental US; may vary elsewhere |
| Stability | ≥ 4 years |
| SKU | CAYM-44290-1 |
|---|---|
| Supplier Part Number | 44290-1 |
| UM | EA |
| UNSPSC | 12352200 |
| Manufacturer | Cayman |
| Temperature | -20 |
| Refrigerated-Frozen | Y |
| CountryOfOrigin | United States |
| ProductLine | CAYM |
| Qty | 1 |
| MinOrderQty | 1 |
| Weight | 7.000000 |
| Lead Time | 5 |
| Hazardous | N |
| CAS Number | 3007772-60-0 |
| Energy Star | No |
| Green | No |
| Controlled | N |