We use cookies to make your experience better. To comply with the new e-Privacy directive, we need to ask for your consent to set the cookies. Learn about our cookie policy.
Cayman JAB-2485, 1 mg
List Price $215.00 Your Price $215.00
Cayman JAB-2485, 1 mg-CAYM (Additional S&H Or Hazmat Fees May Apply)
NETA PART: CAYM-44291-1
MFG.PART: 44291-1
UNSPSC: 12352200
Manufacturer: Cayman
Product Description
JAB-2485 is an inhibitor of Aurora A kinase (IC50 = 0.327 nM).1 It is selective for Aurora A over Aurora B and Aurora C kinases at 2 µM. JAB-2485 decreases levels of phosphorylated Aurora A kinase in NCI H446 small-cell lung cancer cells (IC50 = 2.08 nM) and reduces the viability of 11 lung cancer cell lines (IC50s = 29.7-982 nM). JAB-2485 (0.3, 1, and 3 µM) induces apoptosis and cell cycle arrest at the g2/M phase in NCI H446 cells. It decreases tumor volume without affecting body weight in an NCI H446 mouse xenograft model when administered at doses of 10 or 20 mg/kg per day.
WARNING This product is not for human or veterinary use.
Technical Information
| Formal Name | 1-[(3-chloro- |
| CAS Number | 2899209-55-1 |
| Molecular Formula | C25H28ClF2N5O2 |
| Formula Weight | 504.0 |
| Purity | ≥98% |
| Formulation(Request formulation change) | A solid |
| Solubility(Learn about Variance in Solubility) | Acetonitrile: Slightly soluble: 0.1-1 mg/mL |
| SMILES | FC(C(Cl)=CC=C1)=C1CN2CC[C@](C(O)=O)(CC3=CC(C)=C(F)C(NC4=CC(C)=NN4)=N3)C[C@H]2C |
| InChi Code | InChI=1S/C25H28ClF2N5O2/c1-14-9-18(29-23(21(14)27)30-20-10-15(2)31-32-20)12-25(24(34)35)7-8-33(16(3)11-25)13-17-5-4-6-19(26)22(17)28/h4-6,9-10,16H,7-8,11-13H2,1-3H3,(H,34,35)(H2,29,30,31,32)/t16-,25-/m1/s1 |
| InChi Key | CEONSWRDFKMFNM-PUAOIOHZSA-N |
Shipping & Storage Information
| Storage | -20°C |
| Shipping | Room temperature in continental US; may vary elsewhere |
| Stability | ≥ 4 years |
| SKU | CAYM-44291-1 |
|---|---|
| Supplier Part Number | 44291-1 |
| UM | EA |
| UNSPSC | 12352200 |
| Manufacturer | Cayman |
| Temperature | -20 |
| Refrigerated-Frozen | Y |
| CountryOfOrigin | United States |
| ProductLine | CAYM |
| Qty | 1 |
| MinOrderQty | 1 |
| Weight | 7.000000 |
| Lead Time | 5 |
| Hazardous | N |
| CAS Number | 2899209-55-1 |
| Energy Star | No |
| Green | No |
| Controlled | N |