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Cayman WEHI-539 (hydrochloride), 1 mg
List Price $63.00 Your Price $63.00
Cayman WEHI-539 (hydrochloride), 1 mg-CAYM (Additional S&H Or Hazmat Fees May Apply)
NETA PART: CAYM-44330-1
MFG.PART: 44330-1
UNSPSC: 41116107
Manufacturer: Cayman
Product Description
WEHI-539 is an inhibitor of Bcl-xL (IC50 = 1.1 nM).1 It selectively binds to Bcl-xL (Kd = 1.4 nM) over Bcl-2, myeloid cell leukemia-1 (Mcl-1), Bcl-W, and Bfl-1, also known as Bcl-2-related protein A1 (Kds = >750, >550, >550, and >550 nM, respectively). It selectively induces apoptosis in Mcl-1-deficient mouse embryonic fibroblasts (MEFs) over wild-type MEFs, Bcl-xL- or Bcl-2-deficient MEFs, and Mcl-1-overexpressing MEFs. WEHI-539 (1 µM) also induces apoptosis in SW480 colorectal cancer cells.2
WARNING This product is not for human or veterinary use.
Technical Information
| Formal Name | 5-[3-[4-(amino |
| CAS Number | 2070018-33-4 |
| Molecular Formula | C31H29N5O3S2 • HCl |
| Formula Weight | 620.2 |
| Purity | ≥95% |
| Formulation(Request formulation change) | A solid |
| Solubility(Learn about Variance in Solubility) | Acetonitrile: Slightly soluble: 0.1-1 mg/mLDMSO: Slightly soluble: 0.1-1 mg/mLWater: Slightly soluble: 0.1-1 mg/mL |
| SMILES | O=C(C1=C(CCCOC2=CC=C(CN)C=C2)SC(C3=CC(C(CCC4)=NNC5=NC6=C(S5)C=CC=C6)=C4C=C3)=N1)O.Cl |
| InChi Code | InChI=1S/C31H29N5O3S2.ClH/c32-18-19-10-14-22(15-11-19)39-16-4-9-27-28(30(37)38)34-29(40-27)21-13-12-20-5-3-7-24(23(20)17-21)35-36-31-33-25-6-1-2-8-26(25)41-31;/h1-2,6,8,10-15,17H,3-5,7,9,16,18,32H2,(H,33,36)(H,37,38);1H |
| InChi Key | GJBYTVIQTMIXGA-UHFFFAOYSA-N |
Shipping & Storage Information
| Storage | -20°C |
| Shipping | Room temperature in continental US; may vary elsewhere |
| Stability | ≥ 4 years |
| SKU | CAYM-44330-1 |
|---|---|
| Supplier Part Number | 44330-1 |
| UM | EA |
| UNSPSC | 41116107 |
| Manufacturer | Cayman |
| Temperature | -20 |
| Refrigerated-Frozen | Y |
| ProductLine | CAYM |
| Qty | 1 |
| MinOrderQty | 1 |
| Weight | 7.000000 |
| Lead Time | 5 |
| Hazardous | N |
| CAS Number | 2070018-33-4 |
| Energy Star | No |
| Green | No |
| Controlled | N |