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Cayman BI-907828, 1 mg
List Price
$47.00
Your Price
$47.00
Cayman BI-907828, 1 mg-CAYM (Additional S&H Or Hazmat Fees May Apply)
NETA PART:
CAYM-44353-1
MFG.PART:
44353-1
UNSPSC:
41116134
Manufacturer:
Cayman
Product Description
BI-907828 is an inhibitor of the protein-protein interaction between p53 and murine double minute 2 (MDM2; IC50 = 2 nM in a cell-free assay).1 It is selective for the p53-MDM2 interaction over the p53-MDMX interaction (IC50 = 7,944 nM). BI-907828 selectively inhibits the proliferation of Colon-26 colon cancer cells, which express wild-type p53, over 4T1 breast and MC-38 colon cancer cells, which express mutant p53 (IC50s = 259, 5,579, and 9,782 nM, respectively). It inhibits the proliferation of SJSA-1 osteosarcoma cells, BJ human foreskin fibroblasts, and hTERT RPE-1 retinal pigment epithelial cells but only induces apoptosis in SJSA-1 cells. BI-907828 induces tumor regression in an SJSA-1 mouse xenograft model and patient-derived xenograft (PDX) models.
WARNING This product is not for human or veterinary use.
Technical Information
| Formal Name | (2′S,3′S, 3′aS,10′aS)-6-chloro-3′-(3-chloro-2-fluorophenyl)-1′-(cyclopropylmethyl)-1,2,3′,3′a,10′,10′a-hexahydro-6′-methyl-2-oxo-spiro[3H-indole-3,2′(1′H)-pyrrolo[2′,3′:4,5]pyrrolo[1,2-b]indazole]-7′carboxylic acid |
| CAS Number | 2095116-40-6 |
| Synonyms |
|
| Molecular Formula | C31H25Cl2FN4O3 |
| Formula Weight | 591.5 |
| Purity | ≥98% |
| Formulation(Request formulation change) | A solid |
| Solubility(Learn about Variance in Solubility) | DMSO: Slightly soluble: 0.1-1 mg/mL |
| SMILES | OC(C1=C(C)C2=NN([C@@]([C@]3([H])C4)([H])[C@H](C5=C(C(Cl)=CC=C5)F)[C@@]6(C7=CC=C(Cl)C=C7NC6=O)N3CC8CC8)C4=C2C=C1)=O |
| InChi Code | InChI=1S/C31H25Cl2FN4O3/c1-14-17(29(39)40)8-9-18-23-12-24-28(38(23)36-27(14)18)25(19-3-2-4-21(33)26(19)34)31(37(24)13-15-5-6-15)20-10-7-16(32)11-22(20)35-30(31)41/h2-4,7-11,15,24-25,28H,5-6,12-13H2,1H3,(H,35,41)(H,39,40)/t24-,25-,28+,31+/m0/s1 |
| InChi Key | AMTXDBGKYPDTTA-SJVQGLCSSA-N |
Shipping & Storage Information
| Storage | -20°C |
| Shipping | Room temperature in continental US; may vary elsewhere |
| Stability | ≥ 4 years |
| SKU | CAYM-44353-1 |
|---|---|
| Supplier Part Number | 44353-1 |
| UM | EA |
| UNSPSC | 41116134 |
| Manufacturer | Cayman |
| Temperature | -20 |
| Refrigerated-Frozen | Y |
| CountryOfOrigin | China |
| ProductLine | CAYM |
| Qty | 1 |
| MinOrderQty | 1 |
| Weight | 7.000000 |
| Lead Time | 5 |
| Hazardous | Y |
| CAS Number | 2095116-40-6 |
| Energy Star | No |
| Green | No |
| Controlled | N |