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Cayman PF-06939999 (hydrochloride), 1 mg
List Price $251.00 Your Price $251.00
Cayman PF-06939999 (hydrochloride), 1 mg-CAYM (Additional S&H Or Hazmat Fees May Apply)
NETA PART: CAYM-44357-1
MFG.PART: 44357-1
UNSPSC: 41116134
Manufacturer: Cayman
Product Description
PF-06939999 is an inhibitor of protein arginine methyltransferase 5 (PRMT5; Ki = <5 pM).1 It is selective for PRMT5 over a panel of 22 additional protein methyltransferases and a panel of 40 kinases at 10 µM. PF-06939999 decreases global symmetric dimethyl arginine levels (IC50 = 1.1 nM) but does not affect histone methylation levels in A-427 non-small cell lung cancer (NSCLC) cells. In vivo, PF-06939999 (3, 10, and 30 mg/kg) reduces tumor volume in an A-427 mouse xenograft model.
WARNING This product is not for human or veterinary use.
Technical Information
| Formal Name | (1S,2S,3S,5R)-3-[[6-(difluoromethyl)-5-fluoro-1,2,3,4-tetrahydro-8-isoquinolinyl]oxy]-5-(4-methyl-7H-pyrrolo[2,3-d]pyrimidin-7-yl)-1,2-cyclopentanediol, dihydrochloride |
| Synonyms |
|
| Molecular Formula | C22H23F3N4O3 • 2HCl |
| Formula Weight | 521.3 |
| Purity | ≥98% |
| Formulation(Request formulation change) | A solid |
| Solubility(Learn about Variance in Solubility) | Acetonitrile: Slightly soluble: 0.1-1 mg/mLWater: Slightly soluble: 0.1-1 mg/mL |
| SMILES | O[C@H]1[C@@H](C[C@@H]([C@H]1O)OC2=C3C(CCNC3)=C(C(C(F)F)=C2)F)N4C5=NC=NC(C)=C5C=C4.Cl.Cl |
| InChi Code | InChI=1S/C22H23F3N4O3.2ClH/c1-10-11-3-5-29(22(11)28-9-27-10)15-7-17(20(31)19(15)30)32-16-6-13(21(24)25)18(23)12-2-4-26-8-14(12)16;;/h3,5-6,9,15,17,19-21,26,30-31H,2,4,7-8H2,1H3;2*1H/t15-,17+,19+,20-;;/m1../s1 |
| InChi Key | UGQRIWIWRZAVBW-LACPWWQDSA-N |
Shipping & Storage Information
| Storage | -20°C |
| Shipping | Room temperature in continental US; may vary elsewhere |
| Stability | ≥ 4 years |
| SKU | CAYM-44357-1 |
|---|---|
| Supplier Part Number | 44357-1 |
| UM | EA |
| UNSPSC | 41116134 |
| Manufacturer | Cayman |
| Temperature | -20 |
| Refrigerated-Frozen | Y |
| CountryOfOrigin | United States |
| ProductLine | CAYM |
| Qty | 1 |
| MinOrderQty | 1 |
| Weight | 7.000000 |
| Lead Time | 5 |
| Hazardous | N |
| Energy Star | No |
| Green | No |
| Controlled | N |