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Cayman WHI-P180 (hydrochloride), 10 mg
List Price $75.00 Your Price $75.00
Cayman WHI-P180 (hydrochloride), 10 mg-CAYM (Additional S&H Or Hazmat Fees May Apply)
NETA PART: CAYM-44365-10
MFG.PART: 44365-10
UNSPSC: 41116134
Manufacturer: Cayman
Product Description
WHI-P180 is a multi-kinase inhibitor with IC50 values of 4.5 and 66 nM for the human proto-oncogene RET and kinase insert domain receptor (KDR), respectively.1 It also inhibits EGFR (IC50 = 4 μM) and binds to tau-tubulin kinase 1 (TTBK1; Kds = 0.46 and 0.24 μM for phosphorylated and non-phosphorylated TTBK1, respectively).2,3 WHI-P180 inhibits JAK3 and JAK3-driven graft versus host disease responses in mice receiving allogenic bone marrow and splenocyte grafts.2,4 WHI-P180 (25 mg/kg, i.p) inhibits IgE-induced vascular hyperpermeability in a mouse model of passive anaphylaxis.5
WARNING This product is not for human or veterinary use.
Technical Information
| Formal Name | 3-[(6,7-dimethoxy-4-quinazolinyl)amino]-phenol, monohydrochloride |
| CAS Number | 153437-55-9 |
| Molecular Formula | C16H15N3O3 • HCl |
| Formula Weight | 333.8 |
| Purity | ≥95% |
| Formulation(Request formulation change) | A solid |
| SMILES | COC1=CC2=NC=NC(NC3=CC(O)=CC=C3)=C2C=C1OC.Cl |
| InChi Code | InChI=1S/C16H15N3O3.ClH/c1-21-14-7-12-13(8-15(14)22-2)17-9-18-16(12)19-10-4-3-5-11(20)6-10;/h3-9,20H,1-2H3,(H,17,18,19);1H |
| InChi Key | MJLLZROGIFJFJJ-UHFFFAOYSA-N |
Shipping & Storage Information
| Storage | -20°C |
| Shipping | Room temperature in continental US; may vary elsewhere |
| Stability | ≥ 4 years |
| SKU | CAYM-44365-10 |
|---|---|
| Supplier Part Number | 44365-10 |
| UM | EA |
| UNSPSC | 41116134 |
| Manufacturer | Cayman |
| Temperature | -20 |
| Refrigerated-Frozen | Y |
| CountryOfOrigin | China |
| ProductLine | CAYM |
| Qty | 1 |
| MinOrderQty | 1 |
| Weight | 7.000000 |
| Lead Time | 5 |
| Hazardous | N |
| CAS Number | 153437-55-9 |
| Energy Star | No |
| Green | No |
| Controlled | N |