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Cayman Monomethyl Auristatin E-d8, 1 mg
List Price $1,429.00 Your Price $1,429.00
Cayman Monomethyl Auristatin E-d8, 1 mg-CAYM (Additional S&H Or Hazmat Fees May Apply)
NETA PART: CAYM-44386-1
MFG.PART: 44386-1
UNSPSC: 12352200
Manufacturer: Cayman
Product Description
Monomethyl auristatin E-d8 is intended for use as an internal standard for the quantification of monomethyl auristatin E (MMAE; Item No. 16267) by GC- or LC-MS. MMAE is a derivative of dolastatin 10 and an inhibitor of tubulin polymerization.1 It inhibits the assembly of MAP-rich tubulin and alters the morphology of microtubule ends in cell-free assays when used at concentrations ranging from 1 to 10 µM. MMAE induces cell cycle arrest at the g2/M phase in, and inhibits the proliferation of, MCF-7 cells (IC50s = 0.5 and 0.9 nM, respectively). It is cytotoxic against a panel of nine lymphoma cell lines (IC50s = 0.039-1.35 nM).2 MMAE has been used as the cytotoxic payload component of antibody-drug conjugates (ADCs) with anticancer activity in vitro and in animal models.1,2
WARNING This product is not for human or veterinary use.
Technical Information
| Formal Name | N-methyl-L- |
| CAS Number | 2070009-72-0 |
| Synonyms |
|
| Molecular Formula | C39H59D8N5O7 |
| Formula Weight | 726.0 |
| Purity | ≥99% deuterated forms (d1-d8) |
| Formulation(Request formulation change) | A solid |
| Solubility(Learn about Variance in Solubility) | Acetonitrile: SolubleDMF: SolubleDMSO: SolubleMethanol: Soluble |
| SMILES | O[C@@H](C1=CC=CC=C1)[C@@H](C)NC([C@H](C)[C@H]([C@@]2([H])N(CCC2)C(C[C@@H](OC)[C@H]([C@@H](C)CC)N(C)C([C@@](C(C([2H])([2H])[2H])([2H])C([2H])([2H])[2H])([2H])NC([C@@H](NC)C(C)C)=O)=O)=O)OC)=O |
| InChi Code | InChI=1S/C39H67N5O7/c1-13-25(6)34(43(10)39(49)33(24(4)5)42-38(48)32(40-9)23(2)3)30(50-11)22-31(45)44-21-17-20-29(44)36(51-12)26(7)37(47)41-27(8)35(46)28-18-15-14-16-19-28/h14-16,18-19,23-27,29-30,32-36,40,46H,13,17,20-22H2,1-12H3,(H,41,47)(H,42,48)/t25-,26+,27+,29-,30+,32-,33-,34-,35+,36+/m0/s1/i4D3,5D3,24D,33D |
| InChi Key | DASWEROEPLKSEI-CMHCZSPYSA-N |
Shipping & Storage Information
| Storage | -20°C |
| Shipping | Room temperature in continental US; may vary elsewhere |
| Stability | ≥ 4 years |
| SKU | CAYM-44386-1 |
|---|---|
| Supplier Part Number | 44386-1 |
| UM | EA |
| UNSPSC | 12352200 |
| Manufacturer | Cayman |
| Temperature | -20 |
| Refrigerated-Frozen | Y |
| CountryOfOrigin | Canada |
| ProductLine | CAYM |
| Qty | 1 |
| MinOrderQty | 1 |
| Weight | 7.000000 |
| Lead Time | 5 |
| Hazardous | N |
| CAS Number | 2070009-72-0 |
| Energy Star | No |
| Green | No |
| Controlled | N |