We use cookies to make your experience better. To comply with the new e-Privacy directive, we need to ask for your consent to set the cookies. Learn about our cookie policy.
Cayman DBPR112, 1 mg
List Price $25.00 Your Price $25.00
Cayman DBPR112, 1 mg-CAYM (Additional S&H Or Hazmat Fees May Apply)
NETA PART: CAYM-44448-1
MFG.PART: 44448-1
UNSPSC: 12352200
Manufacturer: Cayman
Product Description
DBPR112 is an inhibitor of EGFR and dual-mutant EGFRL858R/T790M (IC50s = 15 and 48 nM, respectively).1 It is selective for these kinases over 384 other kinases but does inhibit 11 additional kinases, including JAK3, Blk, and bone marrow tyrosine kinase on chromosome X (BMX), at 10,000 nM. DBPR112 reduces the viability of HCC827 and H1975 non-small cell lung cancer (NSCLC) cells with 50% cytotoxicity concentration values (CC50s) of 25 and 620 nM, respectively. It decreases tumor weight without affecting body weight in a HCC827 mouse xenograft model when administered at doses of 20 or 50 mg/kg per day.
WARNING This product is not for human or veterinary use.
Technical Information
| Formal Name | (2E)-4- |
| CAS Number | 1226549-49-0 |
| Synonyms |
|
| Molecular Formula | C32H31N5O3 |
| Formula Weight | 533.6 |
| Purity | ≥95% |
| Formulation(Request formulation change) | A solid |
| Solubility(Learn about Variance in Solubility) | DMSO: Soluble: ≥ 10 mg/mLEthanol: Soluble: ≥ 10 mg/mL |
| SMILES | OC[C@H](C1=CC=CC=C1)NC2=C3C(OC(C4=CC=CC=C4)=C3C5=CC(NC(/C=C/CN(C)C)=O)=CC=C5)=NC=N2 |
| InChi Code | InChI=1S/C32H31N5O3/c1-37(2)18-10-17-27(39)35-25-16-9-15-24(19-25)28-29-31(36-26(20-38)22-11-5-3-6-12-22)33-21-34-32(29)40-30(28)23-13-7-4-8-14-23/h3-17,19,21,26,38H,18,20H2,1-2H3,(H,35,39)(H,33,34,36)/b17-10+/t26-/m1/s1 |
| InChi Key | NQAMTZUVRFRJCZ-VMMYIZNOSA-N |
Shipping & Storage Information
| Storage | -20°C |
| Shipping | Room temperature in continental US; may vary elsewhere |
| Stability | ≥ 4 years |
| SKU | CAYM-44448-1 |
|---|---|
| Supplier Part Number | 44448-1 |
| UM | EA |
| UNSPSC | 12352200 |
| Manufacturer | Cayman |
| Temperature | -20 |
| Refrigerated-Frozen | Y |
| CountryOfOrigin | China |
| ProductLine | CAYM |
| Qty | 1 |
| MinOrderQty | 1 |
| Weight | 7.000000 |
| Lead Time | 5 |
| Hazardous | N |
| CAS Number | 1226549-49-0 |
| Energy Star | No |
| Green | No |
| Controlled | N |