Cayman EP4 Receptor (rat) Activation Assay Kit (cAMP), 1 ea

Product Description

The EP₄ receptor is one of four GPCRs that mediate the actions of prostaglandin E₂ (PGE₂). The diverse effects of PGE₂ acting via EP₄ receptors point to the need to identify novel agonists and antagonists, both to further elucidate the function of this receptor subtype and for use as therapeutics for various diseases. Caymans EP₄ Receptor (rat) Activation Assay Kit (cAMP) consists of a 96-well plate coated with a transfection complex containing a DNA construct for rat EP₄ Receptor (EP₄ Reverse Transfection Strip Plate). Cells grown on the transfection complex will express EP₄ at the cell surface. Binding of agonists to EP₄ stimulates cAMP generation and increases intracellular cAMP levels, which can be measured by a competitive EIA using the Mouse Anti-Rabbit IgG Coated Plate and the reagents included in the kit. An EP₄ agonist, PGE₂, is included in the kit as a positive control.

WARNING This product is not for human or veterinary use.

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