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Sigma-Aldrich Roxadustat
List Price $56.84 Your Price $56.84
Sigma-Aldrich Roxadustat - SIAL (Additional S&H or Hazmat Fees May Apply)
NETA PART: SIAL-SML4224-10MG
MFG.PART: SML4224-10MG
UNSPSC: 12352200
Manufacturer: Sigma-Aldrich
Quality Level
100
assay
≥98% (HPLC)
form
powder
color
white to beige
solubility
DMSO: 2 mg/mL, clear
storage temp.
-10 to -25°C
Biochem/physiol Actions
Orally active hypoxia-inducible factor (HIF) prolyl hydroxylase (HIF-pH) PHD inhibitor with erythropoiesis-stimulatory efficacy in vivo.
Roxadustat (FG-4592) is an orally active hypoxia-inducible factor (HIF) prolyl hydroxylase (HIF-pH) PHD inhibitor that enhances the expression of hypoxia early response genes in cultures and in vivo by stabilizing HIF. Roxadustat protects PC12 from TBHP-induced apoptosis by upregulating cellular HIF-1α (62% without vs 21% with 6h 20 µM roxadustat pretreatment prior to 4h 150 µM TBHP induction). Roxadustat stimulates circulating EPO production in mice in vivo (40 or 80 mg/kg p.o.).
Roxadustat (FG-4592) is an orally active hypoxia-inducible factor (HIF) prolyl hydroxylase (HIF-pH) PHD inhibitor that enhances the expression of hypoxia early response genes in cultures and in vivo by stabilizing HIF. Roxadustat protects PC12 from TBHP-induced apoptosis by upregulating cellular HIF-1α (62% without vs 21% with 6h 20 µM roxadustat pretreatment prior to 4h 150 µM TBHP induction). Roxadustat stimulates circulating EPO production in mice in vivo (40 or 80 mg/kg p.o.).
| SKU | SIAL-SML4224-10MG |
|---|---|
| Supplier Part Number | SML4224-10MG |
| UM | EA |
| UNSPSC | 12352200 |
| Manufacturer | Sigma-Aldrich |
| ProductLine | SIAL |
| Qty | 1 |
| MinOrderQty | 1 |
| Weight | 7.000000 |
| Lead Time | 9 |
| CAS Number | 808118-40-3 |
| Energy Star | No |
| Green | No |
| Controlled | N |