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Sigma-Aldrich Gsk0660
List Price $370.04 Your Price $370.04
Sigma-Aldrich Gsk0660 - SIAL (Additional S&H or Hazmat Fees May Apply)
NETA PART: SIAL-SML4244-50MG
MFG.PART: SML4244-50MG
UNSPSC: 12352202
Manufacturer: Sigma-Aldrich
Quality Level
100
assay
≥98% (HPLC)
form
powder
color
white to beige
solubility
DMSO: 2 mg/mL, clear
storage temp.
-10 to -25°C
Biochem/physiol Actions
Potent and selective PPARdelta (PPARbeta) antagonist.
GSK0660 is a potent and selective PPARdelta (PPARbeta) agonist (IC50 = 300 nM against GW1516-induced PPARβ/δ reporter activity; IC50 = 155 nM vs >10 µM for PPARα and PPARγ by GW1516 displacement binding assays). GSK0660 effectively antagonizes PPARβ/δ agonist GW501516 (GW1516)-induced target genes expression in multiple cell types, including HuH7, rat L6 myotubes, and mouse BMDMs (1-10 nM GW1516, 100-1000 nM GSK0660).
GSK0660 is a potent and selective PPARdelta (PPARbeta) agonist (IC50 = 300 nM against GW1516-induced PPARβ/δ reporter activity; IC50 = 155 nM vs >10 µM for PPARα and PPARγ by GW1516 displacement binding assays). GSK0660 effectively antagonizes PPARβ/δ agonist GW501516 (GW1516)-induced target genes expression in multiple cell types, including HuH7, rat L6 myotubes, and mouse BMDMs (1-10 nM GW1516, 100-1000 nM GSK0660).
| SKU | SIAL-SML4244-50MG |
|---|---|
| Supplier Part Number | SML4244-50MG |
| UM | EA |
| UNSPSC | 12352202 |
| Manufacturer | Sigma-Aldrich |
| ProductLine | SIAL |
| Qty | 1 |
| MinOrderQty | 1 |
| Weight | 7.000000 |
| Lead Time | 9 |
| CAS Number | 1014691-61-2 |
| Energy Star | No |
| Green | No |
| Controlled | N |