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Sigma-Aldrich Jnj-10397049
List Price $138.04 Your Price $138.04
Sigma-Aldrich Jnj-10397049 - SIAL (Additional S&H or Hazmat Fees May Apply)
NETA PART: SIAL-SML4255-5MG
MFG.PART: SML4255-5MG
UNSPSC: 12350000
Manufacturer: Sigma-Aldrich
Quality Level
100
assay
≥97% (HPLC)
form
powder
color
white to beige
solubility
DMSO: 2 mg/mL, clear
storage temp.
-10 to -25°C
Biochem/physiol Actions
Potent and subtype-selective orexin receptor 2 (OX2R) antagonist in vitro and in vivo.
JNJ-10397049 is a potent and subtype-selective orexin receptor 2 antagonist (pKi = 8.3/OX2R vs. 5.5/OX1R) with little affinity toward a panel of 50 receptors, ion channels and transporters. Blockade of OX2R by JNJ-10397049 antagonizes against orexin B-induced cellular calcium response (pKB = 7.9) and attenuates ethanol self-administration, place preference, and reinstatement in rats in vivo (1, 3, and 10 mg/kg, sc).
JNJ-10397049 is a potent and subtype-selective orexin receptor 2 antagonist (pKi = 8.3/OX2R vs. 5.5/OX1R) with little affinity toward a panel of 50 receptors, ion channels and transporters. Blockade of OX2R by JNJ-10397049 antagonizes against orexin B-induced cellular calcium response (pKB = 7.9) and attenuates ethanol self-administration, place preference, and reinstatement in rats in vivo (1, 3, and 10 mg/kg, sc).
| SKU | SIAL-SML4255-5MG |
|---|---|
| Supplier Part Number | SML4255-5MG |
| UM | EA |
| UNSPSC | 12350000 |
| Manufacturer | Sigma-Aldrich |
| ProductLine | SIAL |
| Qty | 1 |
| MinOrderQty | 1 |
| Weight | 7.000000 |
| Lead Time | 9 |
| CAS Number | 708275-58-5 |
| Energy Star | No |
| Green | No |
| Controlled | N |