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Sigma-Aldrich 740 Y-P Trifluoroacetate
List Price $230.84 Your Price $230.84
Sigma-Aldrich 740 Y-P Trifluoroacetate - SIAL (Additional S&H or Hazmat Fees May Apply)
NETA PART: SIAL-SML4269-5MG
MFG.PART: SML4269-5MG
UNSPSC: 12352107
Manufacturer: Sigma-Aldrich
Quality Level
100
assay
≥95% (HPLC)
form
(Powder or Lyophilized powder or film)
storage condition
desiccated
color
white to off-white
storage temp.
-10 to -25°C
General description
Cell-permeable phosphatidylinositol 3-kinase (PI 3-kinase, PI3K) activator.
740 Y-P is a cell-permeable phosphatidylinositol 3-kinase (PI 3-kinase, PI3K) activator composed of the Drosophila antennapedia-derived membrane-permeant 16-mer sequence RQIKIWFQNRRMKWKK followed by a phosphotyrosine-containing, PDGFR-derived sequence SDGGY(P)MDMS that targets SH2 domains of PI3K p85 regulatory subunit. When applied to serum-starved C2 cells at 50 µg/mL, 740 Y-P is more effective than 10% FCS, 5 ng/mL bFGF or 10 ng/mL EGF in stimulating cell proliferation (% of cells in S-phase post 48h stimulation = 48.3, 42.5, 35.7 and 32.8, respectively). 740 Y-P-induced mitogenic response is blocked by wortmannin or rapamycin, but not MEK inhibitor PD98058.
740 Y-P is a cell-permeable phosphatidylinositol 3-kinase (PI 3-kinase, PI3K) activator composed of the Drosophila antennapedia-derived membrane-permeant 16-mer sequence RQIKIWFQNRRMKWKK followed by a phosphotyrosine-containing, PDGFR-derived sequence SDGGY(P)MDMS that targets SH2 domains of PI3K p85 regulatory subunit. When applied to serum-starved C2 cells at 50 µg/mL, 740 Y-P is more effective than 10% FCS, 5 ng/mL bFGF or 10 ng/mL EGF in stimulating cell proliferation (% of cells in S-phase post 48h stimulation = 48.3, 42.5, 35.7 and 32.8, respectively). 740 Y-P-induced mitogenic response is blocked by wortmannin or rapamycin, but not MEK inhibitor PD98058.
Disclaimer
Hygroscopic Store with dessicant
| SKU | SIAL-SML4269-5MG |
|---|---|
| Supplier Part Number | SML4269-5MG |
| UM | EA |
| UNSPSC | 12352107 |
| Manufacturer | Sigma-Aldrich |
| ProductLine | SIAL |
| Qty | 1 |
| MinOrderQty | 1 |
| Weight | 7.000000 |
| Lead Time | 9 |
| CAS Number | 1236188-16-1 |
| Energy Star | No |
| Green | No |
| Controlled | N |