Sigma-Aldrich O-Glcnacase Inhibitor Tmg 1Pc X 25Mg

Name: Sigma-Aldrich O-Glcnacase Inhibitor Tmg 1Pc X 25Mg
SKU: SIAL-110165CBC-25MG
Price: 234.32 USD

List Price $234.32 Your Price $234.32

Sigma-Aldrich O-Glcnacase Inhibitor Tmg 1Pc X 25Mg - SIAL (Additional S&H or Hazmat Fees May Apply)

NETA PART: SIAL-110165CBC-25MG

MFG.PART: 110165CBC-25MG

UNSPSC: 12352200

Manufacturer: Sigma-Aldrich

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Description

Quality Level

100

SMILES string

CCNC1=N[C@@H]2[C@@H](O)[C@H](O)[C@@H](CO)O[C@@H]2S1

InChI

1S/C9H16N2O4S/c1-2-10-9-11-5-7(14)6(13)4(3-12)15-8(5)16-9/h4-8,12-14H,2-3H2,1H3,(H,10,11)/t4-,5-,6-,7-,8-/m1/s1

InChI key

PPAIMZHKIXDJRN-FMDGEEDCSA-N

Biochem/physiol Actions

Thiamet g is a glycosidase inhibitor

Thiamet g is a potent inhibitor of the enzyme O-GlcNAcase (Ki = 21 nM). The compound is orally bioavailable and crosses the blood brain barrier. Thiamet g leads to an increase in O-GlcNAc-modified proteins in cell-based and in vivo assay systems, and reduces levels of phosphorylated Tau protein in rat cortex and hippocampus.

pictograms

GHS07

signalword

Warning

hcodes

H317

pcodes

P261 - P272 - P280 - P302 + P352 - P333 + P313 - P362 + P364

Hazard Classifications

Skin Sens. 1B

Storage Class

11 - Combustible Solids

wgk_germany

WGK 3

flash_point_f

Not applicable

flash_point_c