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Sigma-Aldrich Atn-161 Trifluoroacetate Salt
List Price
$168.20
Your Price
$168.20
Sigma-Aldrich Atn-161 Trifluoroacetate Salt; 5 mg - SIAL (Additional S&H or Hazmat Fees May Apply)
NETA PART:
SIAL-SML4164-5MG
MFG.PART:
SML4164-5MG
UNSPSC:
12352107
Manufacturer:
Sigma-Aldrich
Quality Level
100
assay
≥95% (HPLC)
form
(Powder or Lyophilized powder or film)
storage condition
desiccated
color
white to off-white
storage temp.
-10 to -25°C
SMILES string
O=C([C@H]1N(C(C)=O)CCC1)N[C@@H](CC2=CN=CN2)C(N[C@@H](CO)C(N[C@@H](CS)C(N[C@@H](CC(N)=O)C(N)=O)=O)=O)=O
General description
ATN-161, an antagonist of the integrin α5β1receptor, is a non-RGD-based integrin binding peptide derived from the synergy region of fibronectin that inhibits the receptors for integrins alpha-vbeta-3 and integrin alpha-5 beta-1. Integrin alpha-5 beta-1 is expressed on endothelial cells and plays a key role in endothelial cell adhesion and migration and may also play a key role in cancer cell invasion and metastasis. ATN-161 exhibits antiangiogenic and antitumor activity.
This noncompetitive inhibitor of the fibronectin PHSRN sequence has the potential to disrupt the function of various integrins involved in tumor angiogenesis and metastasis. It can inhibit the interaction between the SARS-CoV-2 spike protein and its host binding partners.
This noncompetitive inhibitor of the fibronectin PHSRN sequence has the potential to disrupt the function of various integrins involved in tumor angiogenesis and metastasis. It can inhibit the interaction between the SARS-CoV-2 spike protein and its host binding partners.
Application
ATN-161trifluoroacetate salt may be used in studies focusing on angiogenesis andcancer research, particularly in the development of models assessing tumorgrowth and metastasis. It may also be used as a fluorescent probe inresearch to study cellular processes and interactions due to its ability tobind to integrins.
Disclaimer
Hygroscopic
| SKU | SIAL-SML4164-5MG |
|---|---|
| Supplier Part Number | SML4164-5MG |
| UM | EA |
| UNSPSC | 12352107 |
| Manufacturer | Sigma-Aldrich |
| ProductLine | SIAL |
| Qty | 1 |
| MinOrderQty | 1 |
| Weight | 7.000000 |
| Lead Time | 9 |
| Energy Star | No |
| Green | No |
| Controlled | N |