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Sigma-Aldrich Ephos Pd G4
List Price
$1,354.50
Your Price
$1,354.50
Sigma-Aldrich Ephos Pd G4 - SIAL (Additional S&H or Hazmat Fees May Apply)
NETA PART:
SIAL-901220-5G
MFG.PART:
901220-5G
UNSPSC:
12352128
Manufacturer:
Sigma-Aldrich
Product Name
EPhos Pd G4,
form
powder or crystals
Quality Level
100
feature
generation 4
reaction suitability
reaction type: Buchwald-Hartwig Cross Coupling Reaction
reaction type: Heck Reaction
reaction type: Hiyama Coupling
reaction type: Negishi Coupling
reaction type: Sonogashira Coupling
reaction type: Stille Coupling
reaction type: Suzuki-Miyaura Coupling
reagent type: catalyst
reaction type: Cross Couplings
functional group
phosphine
SMILES string
[Pd+]c5c(cccc5)c6c(cccc6)NC.P(C4CCCCC4)(C3CCCCC3)c1c(cccc1c2c(cc(cc2C(C)C)C(C)C)C(C)C)OC(C)C.[S](=O)(=O)([O-])C
InChI
1S/C36H55OP.C13H12N.CH4O3S.Pd/c1-24(2)28-22-32(25(3)4)35(33(23-28)26(5)6)31-20-15-21-34(37-27(7)8)36(31)38(29-16-11-9-12-17-29)30-18-13-10-14-19-30;1-14-13-10-6-5-9-12(13)11-7-3-2-4-8-11;1-5(2,3)4;/h15,20-27,29-30H,9-14,16-19H2,1-8H3;2-7,9-10,14H,1H3;1H3,
Inchi Key
HFYQPKNKOSULDB-UHFFFAOYSA-M
Application
Buchwald palladacycle precatalyst with EPhos ligand for Pd-catalyzed C–N cross-coupling between primary amines and aryl halides to form 2-arylaminooxazoles. Catalyst system was reported with NaOPh (CDS001581).
It is a fourth generation (G4) Buchwald precatalyst that is similar to the third generation (G3) precatalysts except that the amino group on the biphenyl backbone is methylated. This modification helps to prevent the limitations of using the third generation precatalysts. It is air, moisture and thermally-stable and shows good solubility in common organic solvents. BrettPhos Pd G4 is highly useful in cross-coupling reactions. Some of its excellent features include lower catalyst loadings, shorter reaction time, and efficient formation of the active catalytic species and accurate control of ligand: palladium ratio.
It is a fourth generation (G4) Buchwald precatalyst that is similar to the third generation (G3) precatalysts except that the amino group on the biphenyl backbone is methylated. This modification helps to prevent the limitations of using the third generation precatalysts. It is air, moisture and thermally-stable and shows good solubility in common organic solvents. BrettPhos Pd G4 is highly useful in cross-coupling reactions. Some of its excellent features include lower catalyst loadings, shorter reaction time, and efficient formation of the active catalytic species and accurate control of ligand: palladium ratio.
Other Notes
Mechanistic Insight Leads to a Ligand That Facilitates the Pd-Catalyzed Formation of 2-(Hetero)Arylaminooxazoles and 4-(Hetero)Arylaminothiazoles
Storage Class
11 - Combustible Solids
wgk_germany
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
| SKU | SIAL-901220-5G |
|---|---|
| Supplier Part Number | 901220-5G |
| UM | EA |
| UNSPSC | 12352128 |
| Manufacturer | Sigma-Aldrich |
| ProductLine | SIAL |
| Qty | 1 |
| MinOrderQty | 1 |
| Weight | 7.000000 |
| Lead Time | 9 |
| CAS Number | 2132978-44-8 |
| Energy Star | No |
| Green | No |
| Controlled | N |