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Sigma-Aldrich Iodoacetamide-Alkyne-C6
List Price $427.50 Your Price $427.50
Sigma-Aldrich Iodoacetamide-Alkyne-C6; 50 mg - SIAL (Additional S&H or Hazmat Fees May Apply)
NETA PART: SIAL-SML4171-50MG
MFG.PART: SML4171-50MG
UNSPSC: 12352209
Manufacturer: Sigma-Aldrich
Quality Level
100
assay
≥95% (HPLC)
form
powder
color
white to beige
solubility
DMSO: 2 mg/mL, clear
storage temp.
-10 to -25°C
SMILES string
O=C(CI)NCCCCC#C
General description
Iodoacetamide-alkyne C6 (IAA-C6, IA-alkyne-C6, IAM-alkyne-C6) is a bifunctional thiol-reactive probe designed for activity-based protein profiling (ABPP) of reactive cysteine residues in live cells. IA-alkyne probe combines aniodoacetamide group (covalent warhead) for cysteine labeling with an alkynemoiety that serves as a click-chemistry handle, enabling subsequent attachmentof fluorophores or biotin-linked reporter for visualization or enrichment, respectively. Optimal usage concentrations are ≤3 μM for cellular studies and ~100 μM for lysates and tissue homogenates, facilitating comprehensive proteomic analysisof cysteine-dependent enzyme activities and protein functions.
Application
Iodoacetamide-alkyne-C6may be used as a chemical probe for labeling cysteine residues in proteins,allowing for the attachment of fluorophores or biotin for visualization orenrichment in proteomic studies.
Biochem/physiol Actions
Cysteine-reactive ABPP probe enabling live-cell labeling, visualization, and enrichment of thiol-containing proteins.
| SKU | SIAL-SML4171-50MG |
|---|---|
| Supplier Part Number | SML4171-50MG |
| UM | EA |
| UNSPSC | 12352209 |
| Manufacturer | Sigma-Aldrich |
| ProductLine | SIAL |
| Qty | 1 |
| MinOrderQty | 1 |
| Weight | 7.000000 |
| Lead Time | 9 |
| CAS Number | 930800-38-7 |
| Energy Star | No |
| Green | No |
| Controlled | N |