Cayman Interleukin-1β (human) ELISA Kit, 480 wells

Product Description

Interleukin 1 (IL-1) is a name for a family of proteins which includes IL-1α, IL-1β, ILra (Interleukin receptor antagonist) and IL-18. IL-1β is synthesized as 269 amino acid pro-cytokine that is enzymatically cleaved by IL-1β-converting enzyme (ICE) into the active 154 amino acid, 17 kDa peptide mature peptide.^1,2 IL-1β is produced by many cell types including macrophages, monocytes, astrocytes, endothelial cells, smooth muscle cells, keratinocytes, adipocytes, T cells, and eosinophils.³ Although IL-1α and IL-1β exhibit only 26% amino acid identity,¹ they bind to the same cell-surface receptors, IL-1 RI and IL-1 RII, present on a variety of cell types involved in immune or inflammatory responses.^4,5,6 Normal production of IL-1 is critical for mediating host responses to infection and injury.^2,3 Disease states in which IL-1 actively participates include inflammatory diseases, such as arthritis, inflammatory bowel disease, and shock, as well as arteriosclerosis, allergic disease, and some types of cancer.^3,7

Needed but not supplied: Please download the kit booklet to verify if UltraPure Water (Milli-Q or equivalent) or any other components are needed for this assay.

WARNING This product is not for human or veterinary use.

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