Cell Signaling Thpok (D9v5t) Rabbit mAb

Name: Cell Signaling Thpok (D9v5t) Rabbit mAb
SKU: CSSPQ-13205S
Price: 416.00 USD

List Price $416.00 Your Price $416.00

Cell Signaling Thpok (D9v5t) Rabbit mAb - CSSPQ (Additional S&H or Hazmat Fees May Apply)

NETA PART: CSSPQ-13205S

MFG.PART: 13205S

UNSPSC: 41116124

Manufacturer: Cell Signaling

Size	100 µl
Reactivity	H M
Sensitivity	Endogenous
Molecular Weight (kDa)	75
Source/Isotype	Rabbit IgG
Application/Dilution	{Western Blotting: 1:1000, Immunoprecipitation: 1:100}
Storage	Supplied in 10 mm sodium HEPES (pH 7.5), 150 mm NaCl, 100 µg/mL BSA, 50% glycerol and less than 0.02% sodium azide. Store at –20°C. Do not aliquot the antibody.
Specificity/Sensitivity	ThPOK (D9V5T) Rabbit mAb recognizes endogenous levels of total ThPOK protein. This antibody cross-reacts with a 40 kDa protein of unknown origin.
Species Reactivity	Human, Mouse
Source/Purification	Monoclonal antibody is produced by immunizing animals with recombinant human ThPOK protein.
Background	The transcription factor Th-inducing POZ/Krüppel-like factor (ThPOK, ZBTB7B, cKROX, ZFP67) is a transcriptional repressor belonging to the POK/ZBTB family of lymphoid cell development regulators (1). ThPOK is best known as a signature CD4+ Th cell transcription factor that is upregulated during the differentiation of CD4+ Th but not CD8+ cytotoxic T cells (1). Expression of ThPOK in developing T cells represses expression of CD8 and cytotoxic T cell effector genes, and indirectly promotes expression of CD4 by antagonizing RUNX-mediated CD4 repression (2-4). ThPOK expression has also been observed in NKT cells and γδ T cells (5,6).