Cell Signaling Phospho-Stat4 (Tyr693) (D2e4) Rabbit mAb (PE Conjugate)

Name: Cell Signaling Phospho-Stat4 (Tyr693) (D2e4) Rabbit mAb (PE Conjugate)
SKU: CSSPQ-13223S
Price: 493.00 USD

List Price $493.00 Your Price $493.00

Cell Signaling Phospho-Stat4 (Tyr693) (D2e4) Rabbit mAb (PE Conjugate) - CSSPQ (Additional S&H or Hazmat Fees May Apply)

NETA PART: CSSPQ-13223S

MFG.PART: 13223S

UNSPSC: 12352203

Manufacturer: Cell Signaling

Size	100 µl (50 tests)
Reactivity	H
Sensitivity	Endogenous
Source/Isotype	Rabbit IgG
Application/Dilution	{Flow Cytometry (Fixed/Permeabilized): 1:50}
Storage	Supplied in PBS (pH 7.2), less than 0.1% sodium azide and 2 mg/mL BSA. Store at 4°C. Do not aliquot the antibodies. Protect from light. Do not freeze.
Specificity/Sensitivity	Phospho-Stat4 (Tyr693) (D2E4) Rabbit mAb (PE Conjugate) recognizes endogenous levels of Stat4 protein only when phosphorylated at Tyr693.
Species Reactivity	Human
Source/Purification	Monoclonal antibody is produced by immunizing animals with a synthetic phosphopeptide corresponding to residues surrounding Tyr693 of human Stat4 protein.
Background	The Jak-Stat signaling pathway is utilized by a large number of cytokines, growth factors, and hormones (1). Receptor-mediated tyrosine phosphorylation of Jak family members triggers phosphorylation of Stat proteins, resulting in their nuclear translocation, binding to specific DNA elements, and subsequent activation of transcription. The remarkable range and specificity of responses regulated by the Stats is determined, in part, by the tissue-specific expression of different cytokine receptors, Jaks, and Stats, as well as by the combinatorial coupling of various Stat members to different receptors (2). Stat4 is predominantly expressed in the spleen, thymus, and testis and has been most extensively investigated as the mediator of IL-12 responses (3-8). Activation of Stat4 is associated with phosphorylation at Tyr693 (9).