Cell Signaling Phospho-Tbk1/Nak (Ser172) (D52c2) Xp Rabbit mAb (PE Conjugate)

Name: Cell Signaling Phospho-Tbk1/Nak (Ser172) (D52c2) Xp Rabbit mAb (PE Conjugate)
SKU: CSSPQ-13498S
Price: 493.00 USD

List Price $493.00 Your Price $493.00

Cell Signaling Phospho-Tbk1/Nak (Ser172) (D52c2) Xp Rabbit mAb (PE Conjugate) - CSSPQ (Additional S&H or Hazmat Fees May Apply)

NETA PART: CSSPQ-13498S

MFG.PART: 13498S

UNSPSC: 41116124

Manufacturer: Cell Signaling

Size	100 µl (50 tests)
Reactivity	H M
Sensitivity	Endogenous
Source/Isotype	Rabbit IgG
Application/Dilution	{Flow Cytometry (Fixed/Permeabilized): 1:50}
Storage	Supplied in PBS (pH 7.2), less than 0.1% sodium azide and 2 mg/mL BSA. Store at 4°C. Do not aliquot the antibodies. Protect from light. Do not freeze.
Specificity/Sensitivity	Phospho-TBK1/NAK (Ser172) (D52C2) XP® Rabbit mAb (PE Conjugate) recognizes endogenous levels of TBK1 only when phosphorylated at Ser172. This antibody may cross-react with phospho-IKKε.
Species Reactivity	Human, Mouse
Source/Purification	Monoclonal antibody is prepared from animals immunized with a synthetic phosphopeptide corresponding to residues surrounding Ser172 of human TBK1 protein.
Background	TBK1 (TANK-binding kinase 1)/NAK (NF-κB activating kinase) is an IκB kinase (IKK)-activating kinase and can activate IKK through direct phosphorylation (1). TBK1 was identified through association with the TRAF binding protein, TANK, and found to function upstream of NIK and IKK in the activation of NF-κB (2). TBK1 induces IκB degradation and NF-κB activity through IKKβ. TBK1 may mediate IKK and NF-κB activation in response to growth factors that stimulate PKCε activity (1). TBK1 plays a pivotal role in the activation of IRF3 in the innate immune response (3).