Cell Signaling Il-1beta (D3u3e) Rabbit mAb (PE Conjugate)

Name: Cell Signaling Il-1beta (D3u3e) Rabbit mAb (PE Conjugate)
SKU: CSSPQ-13627S
Price: 465.00 USD

List Price $465.00 Your Price $465.00

Cell Signaling Il-1beta (D3u3e) Rabbit mAb (PE Conjugate) - CSSPQ (Additional S&H or Hazmat Fees May Apply)

NETA PART: CSSPQ-13627S

MFG.PART: 13627S

UNSPSC: 41116124

Manufacturer: Cell Signaling

Size	100 µl (50 tests)
Reactivity	H
Sensitivity	Endogenous
Source/Isotype	Rabbit IgG
Application/Dilution	{Flow Cytometry (Fixed/Permeabilized): 1:50}
Storage	Supplied in PBS (pH 7.2), less than 0.1% sodium azide and 2 mg/mL BSA. Store at 4°C. Do not aliquot the antibodies. Protect from light. Do not freeze.
Specificity/Sensitivity	IL-1β (D3U3E) Rabbit mAb (PE Conjugate) recognizes endogenous levels of total IL-1β protein and can detect up to 100 pg of recombinant mature IL-1β. This antibody is not observed to detect endogenous levels of mature IL-1β.
Species Reactivity	Human
Source/Purification	Monoclonal antibody is produced by immunizing animals with recombinant human IL-1β protein.
Background	Interleukin-1β (IL-1β), one of the major caspase-1 targets, is a multifunctional cytokine that is involved in a host of immune and proinflammatory responses (1). It is produced primarily by activated monocytes and macrophages. It signals through various adaptor proteins and kinases that lead to activation of numerous downstream targets (2-6). Human IL-1β is synthesized as a 31 kDa precursor. To gain activity, the precursor must be cleaved by caspase-1 between Asp116 and Ala117 to yield a 17 kDa mature form (7,8). Detection of the 17 kDa mature form of IL-1β is a good indicator of caspase-1 activity.