Cell Signaling Irf-1 (D5e4) Xp Rabbit mAb (Alexa Fluor 488 Conjugate)

Name: Cell Signaling Irf-1 (D5e4) Xp Rabbit mAb (Alexa Fluor 488 Conjugate)
SKU: CSSPQ-14028S
Price: 465.00 USD

List Price $465.00 Your Price $465.00

Cell Signaling Irf-1 (D5e4) Xp Rabbit mAb (Alexa Fluor 488 Conjugate) - CSSPQ (Additional S&H or Hazmat Fees May Apply)

NETA PART: CSSPQ-14028S

MFG.PART: 14028S

UNSPSC: 41116124

Manufacturer: Cell Signaling

Size	100 µl (50 tests)
Reactivity	H M R
Sensitivity	Endogenous
Source/Isotype	Rabbit IgG
Application/Dilution	{Flow Cytometry (Fixed/Permeabilized): 1:50}
Storage	Supplied in PBS (pH 7.2), less than 0.1% sodium azide and 2 mg/mL BSA. Store at 4°C. Do not aliquot the antibody. Protect from light. Do not freeze.
Specificity/Sensitivity	IRF-1 (D5E4) XP® Rabbit mAb (Alexa Fluor® 488 Conjugate) recognizes endogenous levels of total IRF-1 protein.
Species Reactivity	Human, Mouse, Rat
Source/Purification	Monoclonal antibody is produced by immunizing animals with a synthetic peptide corresponding to residues surrounding Pro261 of human IRF-1 protein.
Background	Interferon regulatory factors (IRFs) comprise a family of transcription factors that function within the Jak/Stat pathway to regulate interferon (IFN) and IFN-inducible gene expression in response to viral infection (1). IRFs play an important role in pathogen defense, autoimmunity, lymphocyte development, cell growth, and susceptibility to transformation. The IRF family includes nine members: IRF-1, IRF-2, IRF-9/ISGF3γ, IRF-3, IRF-4 (Pip/LSIRF/ICSAT), IRF-5, IRF-6, IRF-7, and IRF-8/ICSBP. All IRF proteins share homology in their amino-terminal DNA-binding domains. IRF family members regulate transcription through interactions with proteins that share similar DNA-binding motifs, such as IFN-stimulated response elements (ISRE), IFN consensus sequences (ICS), and IFN regulatory elements (IRF-E) (2).