Cell Signaling Coilin (D2l3j) Xp Rabbit mAb

Name: Cell Signaling Coilin (D2l3j) Xp Rabbit mAb
SKU: CSSPQ-14168T
Price: 161.00 USD

List Price $161.00 Your Price $161.00

Cell Signaling Coilin (D2l3j) Xp Rabbit mAb - CSSPQ (Additional S&H or Hazmat Fees May Apply)

NETA PART: CSSPQ-14168T

MFG.PART: 14168T

UNSPSC: 12352203

Manufacturer: Cell Signaling

Size	20 µl
Reactivity	H Mk
Sensitivity	Endogenous
Molecular Weight (kDa)	80
Source/Isotype	Rabbit IgG
Application/Dilution	{Western Blotting: 1:1000, Immunofluorescence (Immunocytochemistry): 1:800}
Storage	Supplied in 10 mm sodium HEPES (pH 7.5), 150 mm NaCl, 100 µg/mL BSA, 50% glycerol and less than 0.02% sodium azide. Store at –20°C. Do not aliquot the antibody.
Specificity/Sensitivity	Coilin (D2L3J) XP® Rabbit mAb recognizes endogenous levels of total coilin protein.
Species Reactivity	Human, Monkey
Source/Purification	Monoclonal antibody is produced by immunizing animals with recombinant protein specific to the carboxy terminus of human coilin protein.
Background	The nuclear protein coilin (COIL) is found in eukaryotic nucleoplasm and serves a marker for sub-organelles known as Cajal bodies (1,2). Cajal bodies (CB) are nuclear structures that are home to various RNA-processing complexes, including those responsible for pre-mRNA splicing, processing of rRNA and histone pre-mRNA, and telomere maintenance (1-3). The presence of coilin protein is essential for CB formation, and the protein plays a role in maintaining Cajal body structural integrity (4,5). Research studies indicate that coilin binds RNA, including telomerase RNA (hTR), pre-rRNA, and U2 snRNA, in addition to DNA (5). Additional research indicates that coilin protein may exhibit specific RNase activity towards hTR and U2 snRNA transcripts, and that this activity may be regulated through phosphorylation of coilin (6).