Cell Signaling Caspase-3 (D3r6y) Rabbit mAb (Ihc Formulated)

Name: Cell Signaling Caspase-3 (D3r6y) Rabbit mAb (Ihc Formulated)
SKU: CSSPQ-14214S
Price: 369.00 USD

List Price $369.00 Your Price $369.00

Cell Signaling Caspase-3 (D3r6y) Rabbit mAb (Ihc Formulated) - CSSPQ (Additional S&H or Hazmat Fees May Apply)

NETA PART: CSSPQ-14214S

MFG.PART: 14214S

UNSPSC: 12352202

Manufacturer: Cell Signaling

Size	100 µl
Reactivity	H
Sensitivity	Endogenous
Source/Isotype	Rabbit IgG
Application/Dilution	{Immunohistochemistry (Paraffin): 1:300}
Storage	Supplied in 10 mm sodium HEPES (pH 7.5), 150 mm NaCl, 100 µg/mL BSA, 50% glycerol and less than 0.02% sodium azide. Store at –20°C. Do not aliquot the antibody.
Specificity/Sensitivity	Caspase-3 (D3R6Y) Rabbit mAb (IHC Formulated) recognizes endogenous levels of total caspase-3 protein by immunohistochemistry.
Species Reactivity	Human
Source/Purification	Monoclonal antibody is produced by immunizing animals with recombinant protein specific to the p20 subunit of human caspase-3 protein.
Background	Caspase-3 (CPP-32, Apopain, Yama, SCA-1) is a critical executioner of apoptosis, as it is either partially or totally responsible for the proteolytic cleavage of many key proteins, such as the nuclear enzyme poly (ADP-ribose) polymerase (PARP) (1). Activation of caspase-3 requires proteolytic processing of its inactive zymogen into activated p17 and p12 fragments. Cleavage of caspase-3 requires the aspartic acid residue at the P1 position (2).