Cell Signaling Patl1/Pat1b (D8p1b) Rabbit mAb

Name: Cell Signaling Patl1/Pat1b (D8p1b) Rabbit mAb
SKU: CSSPQ-14288S
Price: 351.00 USD

List Price $351.00 Your Price $351.00

Cell Signaling Patl1/Pat1b (D8p1b) Rabbit mAb - CSSPQ (Additional S&H or Hazmat Fees May Apply)

NETA PART: CSSPQ-14288S

MFG.PART: 14288S

UNSPSC: 41105803

Manufacturer: Cell Signaling

Size	100 µl
Reactivity	H M R Mk
Sensitivity	Endogenous
Molecular Weight (kDa)	95
Source/Isotype	Rabbit IgG
Application/Dilution	{Western Blotting: 1:1000}
Storage	Supplied in 10 mm sodium HEPES (pH 7.5), 150 mm NaCl, 100 µg/mL BSA, 50% glycerol and less than 0.02% sodium azide. Store at –20°C. Do not aliquot the antibody.
Specificity/Sensitivity	PATL1/PAT1b (D8P1B) recognizes endogenous levels of total PATL1/PAT1b protein. This antibody does not cross-react with PATL2.
Species Reactivity	Human, Mouse, Rat, Monkey
Source/Purification	Monoclonal antibody is produced by immunizing animals with a synthetic peptide corresponding to residues surrounding Tyr432 of human PATL1/PAT1b protein.
Background	PATL1/PAT1b is the human homolog of the evolutionarily conserved Pat1/Mrt1 protein, which was first identified in Saccharomyces cerevisiae (1,2). This protein is a critical component of the RNA decay machinery in the cytoplasmic processing bodies (P-bodies), localized foci of mRNA silencing and degradation (3). PATL1/PAT1b interacts with many key components of the RNA decay machinery. These include the 5’ decapping proteins DDX6/RCK, DCP1, DCP2, EDC4, and the LSm1–7 ring (3,4) as well as the 3’ deadenylation complex of CAF1-CCR4-NOT1 (3).