Cell Signaling T-Bet/Tbx21 (D6n8b) Xp Rabbit mAb (Alexa Fluor 647 Conjugate)

Name: Cell Signaling T-Bet/Tbx21 (D6n8b) Xp Rabbit mAb (Alexa Fluor 647 Conjugate)
SKU: CSSPQ-14307S
Price: 465.00 USD

List Price $465.00 Your Price $465.00

Cell Signaling T-Bet/Tbx21 (D6n8b) Xp Rabbit mAb (Alexa Fluor 647 Conjugate) - CSSPQ (Additional S&H or Hazmat Fees May Apply)

NETA PART: CSSPQ-14307S

MFG.PART: 14307S

UNSPSC: 41116124

Manufacturer: Cell Signaling

Size	100 µl (50 tests)
Reactivity	H
Sensitivity	Endogenous
Source/Isotype	Rabbit IgG
Application/Dilution	{Immunofluorescence (Immunocytochemistry): 1:400 - 1:1600, Flow Cytometry (Fixed/Permeabilized): 1:50}
Storage	Supplied in PBS (pH 7.2), less than 0.1% sodium azide and 2 mg/mL BSA. Store at 4°C. Do not aliquot the antibody. Protect from light. Do not freeze.
Specificity/Sensitivity	T-Bet/TBX21 (D6N8B) XP® Rabbit mAb (Alexa Fluor ® 647 Conjugate) recognizes endogenous levels of total T-Bet/TBX21 protein.
Species Reactivity	Human
Source/Purification	Monoclonal antibody is produced by immunizing animals with a synthetic peptide corresponding to residues surrounding Gly465 of human T-bet/TBX21 protein.
Background	The T-box gene family consists of transcription factors characterized by a related DNA-binding domain (T-box) of approximately 200 amino acids (1,2). The T-box genes exhibit diverse temporal and spatial patterns in the developing embryo. Studies have demonstrated members of this family play crucial roles during embryogenesis in a wide range of organisms by regulating cell fate decisions to establish the early body plan and to regulate later processes underlying organogenesis (3-5). Mutations in T-box genes are associated with many developmental defects (6). Recent studies also indicate potential roles in cancer by members of the T-box family (7-9).