Cell Signaling Phospho-Cdk Substrate (D9v5n) Rabbit mAb

Name: Cell Signaling Phospho-Cdk Substrate Ptpxk (D9v5n) Rabbit mAb
SKU: CSSPQ-14371S
Price: 412.00 USD

List Price $412.00 Your Price $412.00

Cell Signaling Phospho-Cdk Substrate [Ptpxk] (D9v5n) Rabbit mAb - CSSPQ (Additional S&H or Hazmat Fees May Apply)

NETA PART: CSSPQ-14371S

MFG.PART: 14371S

UNSPSC: 12352203

Manufacturer: Cell Signaling

Size	100 µl
Reactivity	All
Sensitivity	Endogenous
Source/Isotype	Rabbit IgG
Application/Dilution	{Western Blotting: 1:1000, Immunoprecipitation: 1:100}
Storage	Supplied in 10 mm sodium HEPES (pH 7.5), 150 mm NaCl, 100 µg/mL BSA and 50% glycerol. Store at –20°C. Do not aliquot the antibody.
Specificity/Sensitivity	Phospho-CDK Substrate [pTPXK] (D9V5N) Rabbit mAb recognizes endogenous levels of proteins that are phosphorylated at threonine within the context of a TPXK motif. The antibody does not cross-react with non-phosphorylated proteins or phospho-threonine in a different context.
Species Reactivity	All Species Expected
Source/Purification	Monoclonal antibody is produced by immunizing animals with a synthetic peptide library containing the phospho-TPXK motif.
Background	Cyclin-dependent kinases (CDKs) are a family of Ser/Thr kinases that regulate cell-cycle transition through their association and subsequent phosphorylation of substrate proteins in a proline-directed fashion. CDKs phosphorylate a serine or threonine residue within the (S/T)PX(R/K) consensus sequence (1-5). Cell Signaling Technology has developed antibodies to phosphorylated proline-rich motifs for broad-based discovery applications. The TPXK motif is targeted for phosphorylation by CDKs 1, 2, 4, 5, and 6 (1-5).