Cell Signaling Phospho-Ser-Pro-Pro Motif Rabbit mAb

Name: Cell Signaling Phospho-Ser-Pro-Pro Motif Pspp Rabbit mAb
SKU: CSSPQ-14390S
Price: 412.00 USD

List Price $412.00 Your Price $412.00

Cell Signaling Phospho-Ser-Pro-Pro Motif [Pspp] Rabbit mAb - CSSPQ (Additional S&H or Hazmat Fees May Apply)

NETA PART: CSSPQ-14390S

MFG.PART: 14390S

UNSPSC: 12352203

Manufacturer: Cell Signaling

Size	100 µl
Reactivity	All
Sensitivity	Endogenous
Source/Isotype	Rabbit IgG
Application/Dilution	{Western Blotting: 1:1000}
Storage	Supplied in 10 mm sodium HEPES (pH 7.5), 150 mm NaCl, 100 µg/mL BSA and 50% glycerol. Store at –20°C. Do not aliquot the antibody.
Specificity/Sensitivity	Phospho-Ser-Pro-Pro Motif [pSPP] Rabbit mAb recognizes endogenous levels of proteins only when phosphorylated at serine within the context of the SPP motif. This antibody does not cross-react with proteins phosphorylated at threonine, or with serine residues phosphorylated in other contexts.
Species Reactivity	All Species Expected
Source/Purification	Monoclonal antibody is produced by immunizing animals with a synthetic peptide library containing the phospho-Ser-Pro-Pro motif.
Background	The MAPK and CDK families of serine/threonine protein kinases play important roles in cell signaling and cell cycle control. These kinases phosphorylate threonine or serine followed by a proline residue (1-6). To facilitate the study and discovery of new MAPK and CDK substrates, Cell Signaling Technology has developed antibodies that bind to phospho-threonine or phospho-serine followed by proline.The S/TPP motif matches the consensus sequence for targeted phosphorylation by Cdc2 (7,8), ERK1, ERK2 (9), SAPK/JNK, CDK5, and GSK3 (10).