Cell Signaling Vcam-1 Antibody (Rodent Specific)

Name: Cell Signaling Vcam-1 Antibody (Rodent Specific)
SKU: CSSPQ-14694S
Price: 317.00 USD

List Price $317.00 Your Price $317.00

Cell Signaling Vcam-1 Antibody (Rodent Specific) - CSSPQ (Additional S&H or Hazmat Fees May Apply)

NETA PART: CSSPQ-14694S

MFG.PART: 14694S

UNSPSC: 41116124

Manufacturer: Cell Signaling

Size	100 µl
Reactivity	M R
Sensitivity	Endogenous
Molecular Weight (kDa)	35-45, 85-100
Source/Isotype	Rabbit
Application/Dilution	{Western Blotting: 1:1000}
Storage	Supplied in 10 mm sodium HEPES (pH 7.5), 150 mm NaCl, 100 µg/mL BSA and 50% glycerol. Store at –20°C. Do not aliquot the antibody.
Specificity/Sensitivity	VCAM-1 Antibody recognizes endogenous levels of total VCAM-1 protein. This antibody recognizes both long and short isoforms of VCAM-1 protein.
Species Reactivity	Mouse, Rat
Source/Purification	Polyclonal antibodies are produced by immunizing animals with a synthetic peptide corresponding to residues surrounding Gln203 of mouse VCAM-1 protein. Antibodies are purified by protein A and peptide affinity chromatography.
Background	VCAM-1 (vascular cell adhesion molecule-1) is a transmembrane glycoprotein containing multiple amino-terminal extracellular Ig-like domains, a transmembrane domain, and a short carboxy-terminal cytoplasmic domain (1). Alternative splicing generates two isoforms of VCAM-1 (2). The role of VCAM-1 during infection and inflammatory diseases is well characterized. Expression of VCAM-1 is induced in endothelial cells by inflammatory cytokines including TNF-α and IL-1β (1). VCAM-1 on endothelial cells interacts with the integrin VLA-4 (α4β1) on leukocytes to mediate migration of circulating leukocytes from the blood across the endothelium and into tissues (3).