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Cell Signaling Rb (4h1) Mouse mAb (PE Conjugate)
List Price $465.00 Your Price $465.00
Cell Signaling Rb (4h1) Mouse mAb (PE Conjugate) - CSSPQ (Additional S&H or Hazmat Fees May Apply)
NETA PART: CSSPQ-14731S
MFG.PART: 14731S
UNSPSC: 41116111
Manufacturer: Cell Signaling
| Size | 100 µl (50 tests) |
| Reactivity | H Mk B Pg |
| Sensitivity | Endogenous |
| Source/Isotype | Mouse IgG2a |
| Application/Dilution | {Flow Cytometry (Fixed/Permeabilized): 1:50} |
| Storage | Supplied in PBS (pH 7.2), less than 0.1% sodium azide and 2 mg/mL BSA. Store at 4°C. Do not aliquot the antibodies. Protect from light. Do not freeze. |
| Specificity/Sensitivity | Rb (4H1) Mouse mAb (PE Conjugate) detects endogenous levels of total Rb protein. The antibody does not cross-react with the Rb homologues p107 or p130, or with other proteins. |
| Species Reactivity | Human, Monkey, Bovine, Pig |
| Source/Purification | Monoclonal antibody is produced by immunizing animals with an Rb-C terminal fusion protein containing residues 701-928 of human Rb. |
| Background | The retinoblastoma tumor suppressor protein Rb regulates cell proliferation by controlling progression through the restriction point within the G1-phase of the cell cycle (1). Rb has three functionally distinct binding domains and interacts with critical regulatory proteins including the E2F family of transcription factors, c-Abl tyrosine kinase, and proteins with a conserved LXCXE motif (2-4). Cell cycle-dependent phosphorylation by a CDK inhibits Rb target binding and allows cell cycle progression (5). Rb inactivation and subsequent cell cycle progression likely requires an initial phosphorylation by cyclin D-CDK4/6 followed by cyclin E-CDK2 phosphorylation (6). Specificity of different CDK/cyclin complexes has been observed in vitro (6-8) and cyclin D1 is required for Ser780 phosphorylation in vivo (9). |
| SKU | CSSPQ-14731S |
|---|---|
| Supplier Part Number | 14731S |
| UM | EA |
| UNSPSC | 41116111 |
| Manufacturer | Cell Signaling |
| MSDS URL | Click here |
| Temperature | +4C |
| CountryOfOrigin | United States |
| ProductLine | CSSPQ |
| Qty | 1 |
| MinOrderQty | 1 |
| Weight | 7.000000 |
| Lead Time | 5 |
| Hazardous | N |
| Energy Star | No |
| Green | No |
| Controlled | N |