Cell Signaling Rbmx/Hnrnp g (D7c2v) Rabbit mAb

Name: Cell Signaling Rbmx/Hnrnp g (D7c2v) Rabbit mAb
SKU: CSSPQ-14794S
Price: 351.00 USD

List Price $351.00 Your Price $351.00

Cell Signaling Rbmx/Hnrnp g (D7c2v) Rabbit mAb - CSSPQ (Additional S&H or Hazmat Fees May Apply)

NETA PART: CSSPQ-14794S

MFG.PART: 14794S

UNSPSC: 41105803

Manufacturer: Cell Signaling

Size	100 µl
Reactivity	H M R Mk
Sensitivity	Endogenous
Molecular Weight (kDa)	42
Source/Isotype	Rabbit IgG
Application/Dilution	{Western Blotting: 1:1000, Immunoprecipitation: 1:50}
Storage	Supplied in 10 mm sodium HEPES (pH 7.5), 150 mm NaCl, 100 µg/mL BSA, 50% glycerol and less than 0.02% sodium azide. Store at –20°C. Do not aliquot the antibody.
Specificity/Sensitivity	RBMX/hnRNP g (D7C2V) Rabbit mAb recognizes endogenous levels of total RBMX/hnRNP g protein.
Species Reactivity	Human, Mouse, Rat, Monkey
Source/Purification	Monoclonal antibody is produced by immunizing animals with a synthetic peptide corresponding to residues surrounding Gly265 of human RBMX/hnRNP g protein.
Background	The X-linked RNA binding motif protein (RBMX, hnRNP g) is a multi-functional protein that is part of a heterogeneous nuclear ribonucleoprotein complex (1,2). This widely expressed protein is involved in the control of pre-mRNA splicing as part of the spliceosome. RBMX is important for the alternative splicing of many pre-mRNAs, including those that encode for dystrophin, tropomyosin, and survival motor neuron protein (SMN) in skeletal muscle and cardiac muscle (3,4). The RBMX protein is essential for the maintenance of proper sister chromatid cohesion prior to sister chromosome segregation during mitosis (5). Research studies show that RBMX accumulates at sites of DNA damage and that the presence of RBMX is required for homologous recombination repair (6).