Cell Signaling Bax (D3r2m) Rabbit mAb (Rodent Preferred)

Name: Cell Signaling Bax (D3r2m) Rabbit mAb (Rodent Preferred)
SKU: CSSPQ-14796S
Price: 351.00 USD

List Price $351.00 Your Price $351.00

Cell Signaling Bax (D3r2m) Rabbit mAb (Rodent Preferred) - CSSPQ (Additional S&H or Hazmat Fees May Apply)

NETA PART: CSSPQ-14796S

MFG.PART: 14796S

UNSPSC: 12352202

Manufacturer: Cell Signaling

Size	100 µl
Reactivity	M R
Sensitivity	Endogenous
Molecular Weight (kDa)	20
Source/Isotype	Rabbit IgG
Application/Dilution	{Western Blotting: 1:1000, Immunoprecipitation: 1:50, Immunohistochemistry (Paraffin): 1:400}
Storage	Supplied in 10 mm sodium HEPES (pH 7.5), 150 mm NaCl, 100 µg/mL BSA, 50% glycerol and less than 0.02% sodium azide. Store at –20°C. Do not aliquot the antibody.
Specificity/Sensitivity	Bax (D3R2M) Rabbit mAb recognizes endogenous levels of total Bax protein in rodent samples. It can detect human Bax protein by western blot, but not by other applications.
Species Reactivity	Mouse, Rat
Source/Purification	Monoclonal antibody is produced by immunizing animals with a synthetic peptide corresponding to residues surrounding Leu70 of mouse Bax protein.
Background	Bax is a key component for cellular induced apoptosis through mitochondrial stress (1). Upon apoptotic stimulation, Bax forms oligomers and translocates from the cytosol to the mitochondrial membrane (2). Through interactions with pore proteins on the mitochondrial membrane, Bax increases the membranes permeability, which leads to the release of cytochrome c from mitochondria, activation of caspase-9, and initiation of the caspase activation pathway for apoptosis (3,4).