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Cell Signaling Agpat2 (D8w9b) Rabbit mAb
List Price $351.00 Your Price $351.00
Cell Signaling Agpat2 (D8w9b) Rabbit mAb - CSSPQ (Additional S&H or Hazmat Fees May Apply)
NETA PART: CSSPQ-14937S
MFG.PART: 14937S
UNSPSC: 41122100
Manufacturer: Cell Signaling
| Size | 100 µl |
| Reactivity | H |
| Sensitivity | Endogenous |
| Molecular Weight (kDa) | 27 |
| Source/Isotype | Rabbit IgG |
| Application/Dilution | {Western Blotting: 1:1000, Immunoprecipitation: 1:200} |
| Storage | Supplied in 10 mm sodium HEPES (pH 7.5), 150 mm NaCl, 100 µg/mL BSA, 50% glycerol and less than 0.02% sodium azide. Store at –20°C. Do not aliquot the antibody. |
| Specificity/Sensitivity | AGPAT2 (D8W9B) Rabbit mAb recognizes endogenous levels of total AGPAT2 protein. |
| Species Reactivity | Human |
| Source/Purification | Monoclonal antibody is produced by immunizing animals with a synthetic peptide corresponding to residues surrounding Gly235 of human AGPAT2 protein. |
| Background | The 1-acylglycerol-3-phosphate-O-acyltransferase 2 enzyme (AGPAT2) catalyzes the acylation of lysophosphatidic acid (LPA) into phosphatidic acid (PA), which is a precursor for the synthesis of triacylglycerol and phospholipid (1,2). AGPAT2 is highly expressed in adipose tissues, liver, and skeletal muscle (3). The induced knockdown of AGPAT2 expression results in decreased expression of adipogenic proteins and delayed expression of adipogenic marker proteins, suggesting that AGPAT2 plays an important role in adipocyte growth and differentiation (4). Mutations in the corresponding AGPAT2 gene cause autosomal recessive congenital generalized lipodystrophy type 1 (CGL1), also described as Berardinelli-Seip syndrome. Patients with CGL1 are born without detectable white adipose tissue and tend to develop severe insulin resistance, hypertriglyceridemia, and type 2 diabetes during childhood (5,6). |
| SKU | CSSPQ-14937S |
|---|---|
| Supplier Part Number | 14937S |
| UM | EA |
| UNSPSC | 41122100 |
| Manufacturer | Cell Signaling |
| MSDS URL | Click here |
| Temperature | -20C |
| CountryOfOrigin | United States |
| ProductLine | CSSPQ |
| Qty | 1 |
| MinOrderQty | 1 |
| Weight | 7.000000 |
| Lead Time | 5 |
| Hazardous | N |
| Energy Star | No |
| Green | No |
| Controlled | N |