Cell Signaling Rbm10 Antibody

Name: Cell Signaling Rbm10 Antibody
SKU: CSSPQ-18012S
Price: 317.00 USD

List Price $317.00 Your Price $317.00

Cell Signaling Rbm10 Antibody - CSSPQ (Additional S&H or Hazmat Fees May Apply)

NETA PART: CSSPQ-18012S

MFG.PART: 18012S

UNSPSC: 12352203

Manufacturer: Cell Signaling

Size	100 µl
Reactivity	H R Mk
Sensitivity	Endogenous
Molecular Weight (kDa)	110, 135
Source/Isotype	Rabbit
Application/Dilution	{Western Blotting: 1:1000, Immunoprecipitation: 1:50}
Storage	Supplied in 10 mm sodium HEPES (pH 7.5), 150 mm NaCl, 100 µg/mL BSA and 50% glycerol. Store at –20°C. Do not aliquot the antibody.
Specificity/Sensitivity	RBM10 recognizes endogenous levels of total RBM10 protein.
Species Reactivity	Human, Rat, Monkey
Source/Purification	Polyclonal antibodies are produced by immunizing animals with a synthetic peptide corresponding to residues surrounding Gly53 of human RBM10 protein. Antibodies are purified by protein A and peptide affinity chromatography.
Background	RBM10 is an RNA binding protein and a paralog to tumor suppressor RBM5 (1,2). Alternative splicing creates two highly expressed variants that differ by one exon. RBM10 controls alternative splicing and exon skipping of mRNAs, including Fas and Bcl-x (3,4). RBM10 has been shown to affect apoptosis via up regulation of TNF-α mRNA (5). In lung cancer, RBM10 mutations disrupt the splicing of NUMB, a regulator of Notch signaling (6,7). Fusion of the RBM10 gene with TFE3 has been found in renal cell carcinoma (8-9). Mutations of RBM10 causes TARP syndrome, an x-linked, lethal disorder characterized by various developmental defects (10-12).